Wellcome at the Julius Wolff Institute

Latest Publications

Minkwitz

Minkwitz S, Faßbender M, Kronbach Z, Wildemann B.
Longitudinal Analysis of Osteogenic and Angiogenic Signaling Factors in Healing Models Mimicking Atrophic and Hypertrophic Non-Unions in Rats.
PLoS One. 2015 Apr 24;10(4):e0124217. doi: 10.1371/journal.pone.0124217. eCollection 2015.

We analyzed three different clinically relevant bone healing models to get a better understanding of the molecular changes which are associated with soft tissue damage and failure in revascularization resulting in a hypertrophic and atrophic non-union.

Agres

Agres AN, Duda GN, Gehlen TJ, Arampatzis A, Taylor WR, Manegold S.
Increased unilateral tendon stiffness and its effect on gait 2-6 years after Achilles tendon rupture.
Scand J Med Sci Sports. 2015 Apr 23. doi: 10.1111/sms.12456. [Epub ahead of print]

 

Achilles tendon rupture (ATR) drastically alters tissue composition, tendon mechanics, and ankle function. This retrospective cohort showed lasting changes in tendon stiffness and length, and results suggest that increased tendon stiffness may contribute to deficits in plantarflexion moment generation. These data further support the claim that post-ATR tendon regeneration results in functionally different tissues.

Checa

Checa S, Hesse B, Roschger P, Aido M, Duda GN, Raum K, Willie BM.
Skeletal maturation substantially affects elastic tissue properties in the endosteal and periosteal regions of loaded mice tibiae.
Acta Biomater. 2015 Apr 18. pii: S1742-7061(15)00191-9. doi: 10.1016/j.actbio.2015.04.020. [Epub ahead of print]

 

We analyzed the quality of newly formed and pre-existing bone after in vivo loading. During growth and skeletal maturation, the response of bone to mechanical loading is a deposition of new bone matrix, where tissue amount, but not its mineral or elastic properties are influenced by animal age.

Qazi

Qazi TH, Mooney DJ, Pumberger M, Geißler S, Duda GN.
Biomaterials based strategies for skeletal muscle tissue engineering: Existing technologies and future trends.
Biomaterials. 2015 Jun;53:502-521. doi: 10.1016/j.biomaterials.2015.02.110. Epub 2015 Mar 21. Review.

In this paper, we provide a comprehensive summary of studies where the use of biomaterials in the form of porous scaffolds, hydrogels, and meshes, has benefitted skeletal muscle repair. We present drawbacks associated with systemic and intramuscular bolus injection of cells and growth factors, and argue in favor of utilizing the versatile properties that different biomaterial systems offer to guide and support muscle regeneration. We conclude by outlining future trends in the field that involve an understanding of endogenous healing mechanisms and using this knowledge to develop multifunctional biomaterials which promote tissue regeneration under compromised conditions.

All other publications you will find here

Julius-Wolff-Institut organizes an International Symposium on Bone Regeneration (ISBR)

At the International Symposium on Bone Regeneration (ISBR) we will bring together a wide range of scientists who are specialist in their own fields but who want to understand the complexity of bone regeneration.

We want to explore the relationships and interdependence between immune reactions, cell-matrix interactions and the role of progenitor and stem cells in bone healing.

The symposium offers:
- A panel discussion on the current bone regeneration treatments and the economic impact of non-unions.
- Interactive workshops hosted by two keynote speakers, each from a different field, to discuss the interdependence of immune and progenitor cells and their interaction with the matrix during regeneration.
- Opportunities to present your own work (oral and poster presentations)
- Awards for the three best posters

For more details see  Öffnet externen Link im aktuellen Fensterwww.isbr.eu 

Upcoming Event at Berlin-Brandenburg School for Regenerative Therapies

Research Unit "Regeneration in Aged Individuals"

Unter der Projektleitung von Prof. Georg Duda hat die Deutsche Forschungsgemeinschaft e.V. den Antrag einer Forschergruppe mit dem Arbeitstitel "Regeneration in Aged Individuals: Using bone healing as a model system to characterize regeneration under compromised conditions" für eine Laufzeit von drei Jahren bewilligt.

Die Forschergruppe bezeichnet sich dabei als ein enges Arbeitsbündnis mehrerer Wissenschaftler, die gemeinsam eine Forschungsaufgabe bearbeiten. Neben dem Julius Wolff Institut sind innerhalb der CharitéUniversitätsmedizin Berlin auch die Institute der Medizinischen Genetik und Humangenetik sowie der Medizinischen Immunologie und das Centrum für Muskuloskeletale Chirurgie und das Berlin-Brandenburger Centrum für Regenerative Therapien beteiligt. Weitere Einrichtungen sind das Institut für Biochemie der Freien Universität Berlin und das Deutsches Rheuma-Forschungszentrum Berlin.  Lesen Sie mehr