Petersen et al.; Nature Communications; 2018
Biomaterial-induced endochondral ossification to heal bone defects
Eckstein F. et al.; Osteoarthritis Cartilage; 2018
Normal knee joints with contralateral joint space narrowing may serve as human model of early OA
Klein et al.; Sci Rep.; 2018
MALDI-IMS revealed that early molecular alterations occur largely in the region adjacent to the trauma
Lueckgen et al.; Biomaterials; 2018
Hydrolytically-degradable click-crosslinked alginate hydrogels
Helbig L et al.; BMC Musculoskelet Disord.; 2018
BMP can improve bone-healing in an infected non-union model
Welcome to the Julius Wolff Institute
Following in the tradition of Julius Wolff, we explore the interplay between mechanics and biology in bone and muscle. Motivated by clinical necessities, we concentrate on basic and applied research in orthopedics and trauma surgery. We primary focus on
- understanding the interaction between movement and loading within joint replacements and during fracture healing,
- enable musculoskeletal mobility,
- identification of underlying principles in compromised healing situations, including delayed bone healing, bone defect healing, muscle trauma, ligament injury and arthrosis.
To do so, we develop innovative therapies by applying biomechanical, mechano-biological and osteo-immunological concepts. Translational approaches are supported by infrastructures of the BCRT.
All our PhD Students and Postdocs are members of the BSRT Graduate School and supported by the mentoring infrastructure.
We have a close interaction with our partner clinics CMSC, with whom we have built an international visible focus on "movement research".