Development of combined in-vivo diagnostics

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Towards in-vivo monitoring and stimulation of early callus formation by quantitative focused ultrasound

Cooperation with the Center for Musculoskeletal Surgery and Paris

The aim of this project is the development of a quantitative ultrasound (QUS) based, non-invasive, non-ionising tool for in-vivo monitoring and stimulation of early callus formation in a rat osteotomy model. After in-vitro measurements, 3D micro-elastic models of the osteotomy region will be developed. These models will be used for in-silico sound propagation simulations through the osteotomy gap. Acoustic stimulation levels and sequences required for osteogenic determination of mesenchymal stem cells will be determined in-vitro in cell cultures. The long term goals are to apply this method in small animal bone healing studies and to translate this combined diagnostic/therapeutic concept to the clinical setting.

Publication of the project: Preininger B, Hesse B, Rohrbach D, Varga P, Gerigk H, Langer M, Peyrin F, Perka C, Raum K. Histogram feature-based classification improves differentiability of early bone healing stages from micro-computed tomographic data. J Comput Assist Tomogr. 2012 Jul;36(4):469-76.