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PhD student project: In vivo mechanical loading and tissue adaptation in vertebrae: Inflammation, pain and opioid effects

Brief Description

In the research project "In vivo mechanical loading and tissue adaptation in vertebrae: Inflammation, pain and opioid effects", the interplay between biomechanics and pain is being investigated in an interdisciplinary way. The aim of the PhD project in biomechanics with Prof. Georg Duda is to decipher the interplay between spinal morphology and mechanical loading on the one hand, and inflammation and pain sensing on the other, in order to better understand the framework within which musculoskeletal spinal tissues adapt to mechanical loading and how loading-induced pain can be modulated.

Your Responsibilities

In an in vivo model, the mechanical stress on the spine will be analysed by means of imaging (µCT) as well as histology and histomorphometry. In addition, inflammatory mediators (protons, radicals) and neuropeptides (opioids, substance P) in these and corresponding tissues (spinal cord, posterior root ganglia) as well as resulting local immune modulation will be investigated.

  • Independent collaboration in the scientific FOR project "dyn3M
  • Development of innovative in vivo imaging and combination with histology 
  • Development of strategies for local immunotherapy and pain therapy
  • Cooperation in the network, especially with the project partners from pain research
  • Discussion and presentation of scientific findings in publications and at congresses

Your Profile

  • Completed university studies in biology, immunology, biotechnology, biomaterials, engineering or a comparable discipline.
  • Team-oriented, enthusiastic, independent and flexible
  • Excellent command of written and spoken English
  • Interest in a structured PhD environment


Prof. Dr.Georg Duda (georg.duda(at)

Julius Wolff Institute (JWI) - Center for Musculoskeletal Biomechanics and Regeneration, Charité - Universitätsmedizin Berlin