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10.11.2010

Tanja Schmidt wins Novice Investigator Award 2010

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The prize was awarded to her during the 19th International Congress of the European Association of Tissue Banks (EATB) for her research on soft tissue allografts.

Tanja Schmidt, veterinary scientist at the Julius Wolff Institute has received the Novice Investigator Award 2010. The prize was awarded to her during the 19th International Congress of the European Association of Tissue Banks (EATB) from the 3rd till 5th November 2010 in Berlin for her research on soft tissue allografts.

Tanja Schmidt studied the remodelling and the biomechanical competencies of soft tissue allografts used for anterior cruciate ligament reconstruction. The allogenic grafts had been irradiated with a high dose of Electron Beam (34 kGy) and were analysed after 6 and 12 weeks after the implantation in the cruciate ligament. Histological analysis included vascular, cell and myofibroblasts density assessment. Biomechanical testing included total failure load, stiffness and elongation evaluation.

The results of the histological and biomechanical analyses showed a different remodeling with an increased vascular, cell and myofibroblast density of the irradiated compared to the fresh frozen allografts. The investigations during both time indicated that the irradiated transplants have reduced biomechanical competencies than its control group of fresh frozen allografts.

This study showed that high does Electron Beam irradiation influences the remodeling process of soft tendon allografts and leads to decreased biomechanical properties up to 12 weeks. So at the moment we cannot recommend high dose Electron beam treatment for the sterilization of soft tendon allografts used for ACL reconstruction.



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