Univ.- Prof. Dr.-Ing. Georg Duda

Director
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Research interest

Prof. Dr. Georg Duda is interested in the tension between the fields of Biology and Mechnics. He is involved in investigating the interaction between bone and muscles as well as the biomechnical influences and its impacts in both the intact and injured musculoskeletal system (e.g. loading of joints and bones). Particularly, he focuses on the on the interaction between the physical and mechanical conditions, and the biological regeneration of the musculoskeletal system. By using examples of bone and cartilage healing, he demonstrated the importance of biomechanical characteristics for cells and tissues of the human musculoskeletal system. He showed that a certain amount of mechanical stimulation is helpful to healing, while too much could result in a delay to the healing processes.

Prof. Duda is also involved in the research on regenerative medicine. With his work he aims to understand the body's own processes and, where necessary, to stimulate them, so as to reproduce natural regeneration of the musculoskeletal system.

The basic understanding of mechanical stimulation helps activation of the endogenous healing processes to be targeted, understood and guided.

 

The 10 most important publications

Cipitria A, Lange C, Schell H, Wagermaier W, Reichert JC, Hutmacher DW, Fratzl P, Duda GN
Porous scaffold architecture guides tissue formation.
J Bone Miner Res. 2012 Jun;27(6):1275-88

Boeth H, Duda GN, Heller MO, Ehrig RM, Doyscher R, Jung T, Moewis P, Scheffler S, Taylor WR
Anterior cruciate ligament-deficient patients with passive knee joint laxity have a decreased range of anterior-posterior motion during active movements.
Am J Sports Med. 2013 May;41(5):1051-7

Reinke S, Geissler S, Taylor WR, Schmidt-Bleek K, Juelke K, Schwachmeyer V, Dahne M, Hartwig T, Akyüz L, Meisel C, Unterwalder N, Singh NB, Reinke P, Haas NP, Volk HD, Duda GN
Terminally differentiated CD8+ T cells negatively affect bone regeneration in humans.
Sci Transl Med. 2013 Mar 20;5(177):177ra36

Reichert JC, Cipitria A, Epari DR, Saifzadeh S, Krishnakanth P, Berner A, Woodruff MA, Schell H, Mehta M, Schuetz MA, Duda GN, Hutmacher DW
A tissue engineering solution for segmental defect regeneration in load-bearing long bones.
Sci Transl Med. 2012 Jul 4;4(141):141ra93

Kopf J, Petersen A, Duda GN, Knaus P
BMP2 and mechanical loading cooperatively regulate immediate early signalling events in the BMP pathway.
BMC Biol. 2012 Apr 30;10:37

Szwedowski TD, Taylor WR, Heller MO, Perka C, Müller M, Duda GN
Generic rules of mechano-regulation combined with subject specific loading conditions can explain bone adaptation after THA.
PLoS One. 2012;7(5):e36231

Toben D, Schroeder I, El-Khassawna T, Mehta M, Hoffmann JE, Frisch JT, Schell H, Lienau J, Serra A, Radbruch A, Duda GN
Fracture healing is accelerated in the absence of the adaptive immune system.
J Bone Miner Res. 2011 Jan;26(1):113-24

Kasper G, Ode A, Groothuis A, Glaeser J, Gaber T, Wilson CJ, Geissler S, Duda GN
Validation of beta-actin used as endogenous control for gene expression analysis in mechanobiology studies: amendments.
Stem Cells. 2010 Mar 31;28(3):633-4

Kasper G, Mao L, Geissler S, Draycheva A, Trippens J, Kühnisch J, Tschirschmann M, Kaspar K, Perka C, Duda GN, Klose J
Insights into mesenchymal stem cell aging: involvement of antioxidant defense and actin cytoskeleton.
Stem Cells. 2009 Jun;27(6):1288-97

Kasper G, Glaeser JD, Geissler S, Ode A, Tuischer J, Matziolis G, Perka C, Duda GN
Matrix metalloprotease activity is an essential link between mechanical stimulus and mesenchymal stem cell behavior.
Stem Cells. 2007 Aug;25(8):1985-94

 

 

Vita Univ.- Prof. Dr.-Ing. Georg Duda

Prof. Dr. Georg Duda, born in 1966 in Berlin, received a degree in Precision Engineering and Biomedical Engineering from the Technical University in Berlin. After working as a Special Project Associate in the Biomechanics Lab at the Mayo Clinic (USA) in 1991 and 1992, he became a Ph.D. student in the Biomechanics Department of the Technical University in Hamburg-Harburg where he received his Doctorate in 1996. He was also engaged as a Post Doc in the Section Trauma Research and Biomechanics at the University Ulm. In 1997 he became Head of the research department at the Center for Musculoskeletal Surgery (CMSC) at the Charité. In 2001 he habilitated and accepted a call to a Professorship in "Biomechanics and biology of bone healing". Since 2008 he is the director of the Julius Wolff Institute and W3-Professor for Biomechanics and Musculoskeletal Regeneration.

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