Authors:Schoon J, Hesse B, Tucoulou R, Geissler S, Ort M, Duda GN, Perka C, Wassilew G, Perino G, Rakow A

Title:Synchrotron-based characterization of arthroprosthetic CoCrMo particles in human bone marrow

Journal:J Mater Sci Mater Med Year:2022; Volume:33Issue:(6)

Authors:Peniche Silva CJ, Müller SA, Quirk N, Poh PSP, Mayer C, Motta A, Migliaresi C, Coenen MJ, Evans CH, Balmayor ER, van Griensven M

Title:Enthesis Healing Is Dependent on Scaffold Interphase Morphology-Results from a Rodent Patellar Model

Journal:Cells Year:2022; Volume:11Issue:(11)

Authors:Dias DB, Fritsche-Guenther R, Gutmann F, Duda GN, Kirwan J, Poh PSP

Title:A Comparison of Solvent-Based Extraction Methods to Assess the Central Carbon Metabolites in Mouse Bone and Muscle

Journal:Metabolites Year:2022; Volume:12Issue:(5)

Authors:Niemann M, Otto E, Braun KF, Graef F, Ahmad SS, Hardt S, Stöckle U, Trampuz A, Meller S

Title:Microbiological Advantages of Open Incisional Biopsies for the Diagnosis of Suspected Periprosthetic Joint Infections

Journal:J Clin Med Year:2022; Volume:11Issue:(10)

Authors:Niemann M, Graef F, Ahmad SS, Braun KF, Stöckle U, Trampuz A, Meller S

Title:Outcome Analysis of the Use of Cerament ® in Patients with Chronic Osteomyelitis and Corticomedullary Defects

Journal:Diagnostics (Basel) Year:2022; Volume:12Issue:(5)

Authors:Arshad R, Schmidt H, El-Rich M, Moglo K

Title:Sensitivity of the Cervical Disc Loads, Translations, Intradiscal Pressure, and Muscle Activity Due to Segmental Mass, Disc Stiffness, and Muscle Strength in an Upright Neutral Posture

Journal:Front Bioeng Biotechnol Year:2022; Volume:10

Authors:Young SAE, Rummler M, Taïeb HM, Garske DS, Ellinghaus A, Duda GN, Willie BM, Cipitria A

Title:In vivo microCT-based time-lapse morphometry reveals anatomical site-specific differences in bone (re)modeling serving as baseline parameters to detect early pathological events

Journal:Bone Year:2022; Volume:161

Authors:Aims: The aim of the HIPGEN consortium is to develop the first cell therapy product for hip fracture patients using PLacental-eXpanded (PLX-PAD) stromal cells.

Methods: HIPGEN is a multicentre, multinational, randomized, double-blind, placebo-controlled trial. A total of 240 patients aged 60 to 90 years with low-energy femoral neck fractures (FNF) will be allocated to two arms and receive an intramuscular injection of either 150 × 106 PLX-PAD cells or placebo into the medial gluteal muscle after direct lateral implantation of total or hemi hip arthroplasty. Patients will be followed for two years. The primary endpoint is the Short Physical Performance Battery (SPPB) at week 26. Secondary and exploratory endpoints include morphological parameters (lean body mass), functional parameters (abduction and handgrip strength, symmetry in gait, weightbearing), all-cause mortality rate and patient-reported outcome measures (Lower Limb Measure, EuroQol five-dimension questionnaire). Immunological biomarker and in vitro studies will be performed to analyze the PLX-PAD mechanism of action. A sample size of 240 subjects was calculated providing 88% power for the detection of a 1 SPPB point treatment effect for a two-sided test with an α level of 5%.

Conclusion: The HIPGEN study assesses the efficacy, safety, and tolerability of intramuscular PLX-PAD administration for the treatment of muscle injury following arthroplasty for hip fracture. It is the first phase III study to investigate the effect of an allogeneic cell therapy on improved mobilization after hip fracture, an aspect which is in sore need of addressing for the improvement in standard of care treatment for patients with FNF. Cite this article: Bone Jt Open 2022;3(4):340-347.

Title:HIPGEN: a randomized, multicentre phase III study using intramuscular PLacenta-eXpanded stromal cells therapy for recovery following hip fracture arthroplasty : a study design

Journal:Bone Jt Open Year:2022; Volume:3Issue:(4):Pages:340-347.

Authors:Zhou S, Maleitzke T, Geissler S, Hildebrandt A, Fleckenstein F, Niemann M, Fischer H, Perka C, Duda GN, Winkler T

Title:Source and Hub of Inflammation - The Infrapatellar Fat Pad and its Interactions with Articular Tissues during Knee Osteoarthritis

Journal:J Orthop Res Year:2022;

Authors:Perier-Metz, C, Corté L, Allena R, Checa S

Title:A 3D in Silico Multi-Tissue Evolution Model Highlights the Relevance of Local Strain Accumulation in Bone Fracture Remodeling

Journal:Front Bioeng Biotechnol Year:2022; Volume:10

Authors:Perier-Metz C, Cipitria A, Hutmacher DW, Duda GN, Checa S

Title:An in silico model predicts the impact of scaffold design in large bone defect regeneration

Journal:Acta Biomater Year:2022;

Authors:Haffer H, Bender A, Krump A, Hardt S, Winkler T, Damm P

Title:Is Training With Gym Machines Safe After Hip Arthroplasty?-An In Vivo Load Investigation

Journal:Front Bioeng Biotechnol Year:2022; Volume:10

Authors:Tortorici M, Petersen A, Duda GN, Checa S

Title:The Degradation of Synthetic Polymeric Scaffolds With Strut-like Architecture Influences the Mechanics-dependent Repair Process of an Osteochondral Defect in Silico

Journal:Front Bioeng Biotechnol Year:2022; Volume:10

Authors:Haffer H, Wang Z, Hu Z, Palmowski Y, Hardt S, Schmidt H, Perka C, Pumberger M

Title:Does Total Hip Arthroplasty Affect Spinopelvic and Spinal Alignment?: A Prospective Observational Investigation

Journal:Clin Spine Surg Year:2022;

Authors:Niemann M, Braun KF, Ahmad SS, Stöckle U, Märdian S, Graef F

Title:Comparing Perioperative Outcome Measures of the Dynamic Hip Screw and the Femoral Neck System

Journal:Medicina (Kaunas) Year:2022; Volume:58Issue:(3)

Authors:Alves SA, Polzehl J, Brisson NM, Bender A, Agres AN, Damm P, Duda GN

Title:Ground reaction forces and external hip joint moments predict in vivo hip contact forces during gait

Journal:J Biomech Year:2022; Volume:135

Authors:Damerau A, Kirchner M, Pfeiffenberger M, Ehlers L, Nguyen DHD, Mertins P, Bartek B, Maleitzke T, Palmowski Y, Hardt S, Winkler T, Buttgereit F, Gaber T

Title:Metabolic reprogramming of synovial fibroblasts in osteoarthritis by inhibition of pathologically overexpressed pyruvate dehydrogenase kinases

Journal:Metab Eng Year:2022; Volume:72:Pages:116-132.

Authors:Alves SA, Preuße M, Hommel H, Duda GN, Agres AN

Title:The Recovery of Weight-Bearing Symmetry After Total Hip Arthroplasty Is Activity-Dependent

Journal:Front Bioeng Biotechnol Year:2022; Volume:10

Authors:Freedman B, Knecht RS, Tinguely Y, Ege Eskibozkurt G, Wang CS, Mooney DJ

Title:Aging and Matrix Viscoelasticity Affect Multiscale Tendon Properties and Tendon Derived Cell Behavior

Journal:Acta Biomater Year:2022; Volume:143:Pages:63-71.

Authors:Bender A, Damm P, Hommel H, Duda GN

Title:Overstretching Expectations May Endanger the Success of the "Millennium Surgery"

Journal:Front Bioeng Biotechnol Year:2022;