Large Segmental Bone Defects

Dr. med. vet. Anne-Marie Pobloth



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Histological of a large segmental bone defect filled with a composite scaffold (Safranin Orange van Kossa staining)

The reconstruction of large segmental bone defects caused by trauma, infection or tumor resection are still a clinical concern. Available regenerative treatment options for a biomechanically sufficient restoration are limited. Therefore, we investigate alternative treatment options as the application of mechano-biologically optimized titanium- mesh scaffolds and composite scaffolds for the regeneration of large segmental bone defects.

Magnification of the composite scaffold material within the bone defect (TRAP staining)
New bone formation within the defect (Masson Goldner staining)


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