Mechanical Principles of Cellular Self-Organization
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Cells, the active component of tissues, are continuously interacting with their extracellular matrix (ECM) to maintain, remodel, regenerate or in some cases also degenerate tissue function and properties. Among others, mechanical interactions are fundamental in many physiological and pathological situations such as embryogenesis, wound healing, tumour invasion and connective tissue morphogenesis. We are interested in understanding the mechanical interactions between the cells and the extracellular matrix and their implications for cellular and tissue organization.
Checa S, Rausch M, Petersen A, Kuhl E, Duda G. (2014) The Emergence of Extracellular Matrix Mechanics and Cell Traction Forces as Important Regulators of Cellular Self-organization. Biomechanics and Modeling in Mechanobiology, 14(1):1-13