Mechano-Biological Optimization of Scaffolds
Univ.- Prof. Dr. Sara Checa Esteban
Learn more about our research area mechano-biological optimization of scaffolds.
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Bone regeneration is influenced by the local mechanical and biological environments. We develop computer models to understand the process of tissue regeneration within tissue engineering constructs and apply mechano-biological knowledge to design scaffolds that would promote bone tissue formation in vivo.
Razi H, Checa S, Schaser KD, Duda GN. (2012) Shaping scaffold structures in rapid manufacturing implants: a modeling approach toward mechano-biologically optimized configurations for large bone defect. J Biomed Mater Res B Appl Biomater.; 100(7):1736-45.
Khayyeri H, Checa S, Tägil M, O'Brien FJ, Prendergast PJ. (2010). Tissue differentiation in an in vivo bioreactor: in silico investigations of scaffold stiffness. J Mater Sci Mater Med. 2010 Aug;21(8):2331-6.
Checa S, Prendergast PJ. (2010) Effect of cell seeding and mechanical loading on vascularization and tissue formation inside a scaffold: a mechano-biological model using a lattice approach to simulate cell activity. J. Biomechanics, 43: 961-8.
Sandino C, Checa S, Prendergast PJ, Lacroix D. (2010) Simulation of angiogenesis and cell differentiation in a CaP scaffold subjected to unconfined compressive strain using a lattice modeling approach. Biomaterials, 31: 2446-2452.