Julius Wolff Institut (JWI) - Center for Musculoskeletal Biomechanics and Regeneration 

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Bone Healing

Bone is an interesting tissue from the researchers view as it is able to regenerate after injury. However, even today and with an adequate treatment 5-20% of all fractured patients experience a delayed or non-union.

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Feaured Publications

  • Schlundt C, Reinke S, Geissler S, Bucher CH, Giannini C, Märdian S, Dahne M, Kleber C, Samans B, Baron U, Duda GN, Volk HD, Schmidt-Bleek K

    Individual Effector/Regulator T Cell Ratios Impact Bone Regeneration


    There is increasing evidence that T lymphocytes play a key role in controlling endogenous regeneration. Regeneration Using adoptive TReg transfer, bone healing was consistently improved in mice possessing an inexperienced immune system with low amounts of CD8+ TEFF. In contrast, mice with an experienced immune system (high amounts of CD8+ TEFF) showed heterogeneous bone repair with regeneration being dependent upon the individual TEFF/TReg ratio. Thus, the healing outcome can only be improved by an adoptive TReg therapy, if an unfavorable TEFF/TReg ratio can be reshaped; if the individual CD8+ TEFF percentage, which is dependent on the individual immune experience can be changed toward a favorable ratio by the TReg transfer.

    Front Immunol 2019; 10

  • Bucher C, Schlundt C, Wulsten D, Sass F, Wendler S, Ellinghaus A, Thiele T, Seemann R, Willie B, Volk H, Duda G, Schmidt-Bleek K

    Experience in the Adaptive Immunity Impacts Bone Homeostasis, Remodeling, and Healing


    Bone formation is substantially reduced in aged individual owing to the experience of the adaptive immunity. Thus, immune-aging in addition to chronological aging is a potential risk factor, with an experienced immune system being recognized as more pro-inflammatory. In metaphyseal bone, immune-aging affects bone homeostasis by impacting bone formation capacity and thereby influencing mass and microstructure of bone trabeculae leading to an overall reduced mechanical competence as found in bone torsional testing. Bone formation is impacted during bone regeneration in terms of a diminished healing capacity observed in young animals who have an experienced human immune system. Considering the immune system's experience level will likely allow a more effective differentiation (stratify) and treatment (immune-modulate) of patients .

    Front Immunol 2019; 10:797.


Publications

Results 1 to 10 of total 86


Results 1 to 10 of total 86