Bone Healing

Bone is an interesting tissue from the researchers view as it is able to regenerate after injury. However, even today and with an adequate treatment 5-20% of all fractured patients experience a delayed or non-union.

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Feaured Publications

  • Lang A, Kirchner M, Stefanowski J, Durst M, Weber MC, Pfeiffenberger M, Damerau A, Hauser AE, Hoff P, Duda GN, Buttgereit F, Schmidt-Bleek K, Gaber T

    Collagen I-based scaffolds negatively impact fracture healing in a mouse-osteotomy-model although used routinely in research and clinical application

    Clinical application of bone morphogenetic protein 2 is only approved when applied on an absorbable bovine collagen I scaffold (ACS). Nevertheless, the influence of ACS alone on bone healing remains so far unknown. In vitro studies using ASC-H (Helistat) revealed a suppression of osteogenic differentiation and a reduction of cell vitality compared to ASC-L, another frequently used scaffold. In vivo, a significant delay in bone healing was observed when ACS-L was applied during femoral osteotomy. This negative influence of ACS-H and ACS-L on bone formation demonstraties a substantial need for more sophisticated delivery systems for local stimulation of bone healing.

    Acta Biomater 2019; 86:171-184.

  • El Khassawna T, Serra A, Bucher CH, Petersen A, Schlundt C, Konnecke I, Malhan D, Wendler S, Schell H, Volk HD, Schmidt-Bleek K, Duda GN

    T Lymphocytes Influence the Mineralization Process of Bone

    Comparing bone and fracture healing in animals with and without mature T and B cells revealed their essential role during tissue mineralization processes and thus for the bone quality. Bone without mature T and B cells is stiffer compared to wild-type bone thus lacking the elasticity that helps to absorb forces to prevent fractures. In-depth analysis showed dysregulations in collagen deposition and osteoblast distribution when no mature T and B cells were present. This work presents, for the first time, a direct link between immune cells and matrix formation during bone healing after fracture. It illustrates specifically the role of T cells in the collagen organization process.

    Front Immunol 2017; 8:562.


Results 1 to 10 of total 64

Results 1 to 10 of total 64