Molecular Traumatology
Molecular Traumatology investigates the molecular and cellular basis of clinically relevant issues in musculoskeletal surgery with a focus on the interaction of the nervous system with bone.
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The role of the circadian clock in the bone
Fabian Titz, Sebastian Hitzler, Christine Graffmann, Jason Witte, Paul Köhli, Achim Kramer, Denise Jahn
The internal clock, also known as the circadian clock, synchronizes the body with the day-night rhythm. It regulates body physiology via the sympathetic nervous system, among other factors, which has a strong influence on bone tissue. There are a number of studies that show a circadian rhythm in bone metabolism and demonstrate its necessity for bone health. The influence on fracture healing is still largely unknown. In our projects, we are investigating the role of the circadian clock in bone healing using mouse lines with specific circadian clock disorders. Our aim is to use Circadian Medicine to improve fracture healing and to protect shift workers and other individuals with disrupted circadian rhythms from osteoporosis.