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Immune Modulation - Mesenchymal Stroma Cells
In the clinics, mesenchymal stroma cells (MSC) are applied in patients with dealyed healing or non-union in form of autologous cancelous bone from the iliac crest or as RIA (reaming-irrigation-aspiration) material. MSCs are precurser cells that undergo osteogenic differentiation and therefore can improve healing. However, the efficacy of the cells varies greatly between the patients. We want to improve the micro millieu the cells encounter after implantation into the bone defect in order to enhance their bone forming properties.