Musculoskeletal Advanced Therapies

Despite the high incidence of muscle injuries, degenerative joint or spine diseses and other musculoskeletal disorders like tendon or bone pathologies, the basic issue  - biological regeneration - has not yet been solved in clinical practice. Since 2006 we have been working on translational therapies in the field of musculoskeletal regeneration with the aim to bring innovative regenerative approaches to the patient. 

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Featured Publications

  • Winkler T, Stuhlert MGW, Lieb E, Muller M, von Roth P, Preininger B, Trampuz A, Perka CF

    Outcome of short versus long interval in two-stage exchange for periprosthetic joint infection: a prospective cohort study


    For chronic periprosthetic joint infection, a 6-8 week interval is commonly used before re-implantation. We evaluated the influence of a short (< 4 weeks) and long (>/= 4 weeks) prosthesis-freeinterval on reinfection rate and functional outcome of hip and knee periprosthetic joint infection. Our study suggests that two-stage exchange with short interval has a similar outcome than with long interval, when highly active antibiotic therapy is used. Patient inconvenience and care costs due to immobilization were lower when strategies with a short interval were used.

    Arch Orthop Trauma Surg 2019; 139(4):295-303.

  • Winkler T, Perka C, von Roth P, Agres AN, Plage H, Preininger B, Pumberger M, Geissler S, Hagai EL, Ofir R, Pinzur L, Eyal E, Stoltenburg-Didinger G, Meisel C, Consentius C, Streitz M, Reinke P, Duda GN, Volk HD

    Immunomodulatory placental-expanded, mesenchymal stromal cells improve muscle function following hip arthroplasty


    In this study we addressed surgical trauma-related muscle injuries resulting from Hip arthroplasty by local intraoperative application of allogeneic placenta-derived, mesenchymal-like adherent cells (PLX-PAD). This cell type was used because of its high regenerative and immunomodulatory potency and we could show that this allogeneic PLX-PAD therapy improved strength and volume of the injured skeletal muscle with a reasonable safety profile. Outcomes could be positively correlated with the modulation of early postoperative stress-related immunological reactions.

    J Cachexia Sarcopenia Muscle 2018; 9(5):880-897.


Publications

Results 1 to 10 of total 34


Results 1 to 10 of total 34