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Tendon and Bone Regeneration

Bones represent the supporting structure of the body, whereas the tendons allow our movement by transferring forces from the muscle to the bone. About 20% of all medical consultations are in the musculoskeletal area, of which about 30% are associated with tendon injuries. In addition to bone regeneration, the aim of our research group is to better understand tendon regeneration and thus to develop improved therapies for patients in the future.

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Local application

Healing processes can be promoted by the application of active substances. A major field of research in orthopedics is the application of growth factors for healing stimulation and antibiotics for the prevention and treatment of infections.

Bone healing disorders and implant-associated infections are still a challenge in trauma and orthopedic surgery. Local application of active substances can promote endogenous healing processes, but also prevent or treat infections. At the same time, the necessary dosage and the systemic load is reduced, but also the availability on site is improved. Our group focuses on various possibilities of local application in various indications.

The developed biodegradable coating –based on the polymer poly(D,L-lactide)- for surgical material such as implants was extensively tested in vitro and in vivo for the application of antibiotics and bone healing stimulating factors. In addition to the optimization of the coating and the release kinetics, the effectiveness and biocompatibility was investigated.

Numerous bone substitutes are available for the treatment of bony defects. Ideally, the surgeon can enrich the appropriate material with an active substance to promote healing or fight bacteria. For this purpose, we have developed a perioperative approach which allows a fast and homogeneous mixture of substitute material with active substances and intensively analyzes the release kinetics of various antibiotics in vitro. Using a bone defect model we evaluated the effectivity of a bone graft (demineralized bone matrix, DBM) enriched with the osteoinductive factor BMP-2 by µCT and histology. We investigate the efficacy and cytotoxicity of newly discovered or modified antimicrobial substances in different in vitro approaches.

Selected Publications

Headed by

Univ.- Prof. Dr. rer. nat. Britt Wildemann

Principal Investigator at the JWI &
Professor for Experimental Trauma Surgery in Jena At the JWI: Seit 2000 - Tendon and Bone R