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Tendon and Bone Regeneration

Bones represent the supporting structure of the body, whereas the tendons allow our movement by transferring forces from the muscle to the bone. About 20% of all medical consultations are in the musculoskeletal area, of which about 30% are associated with tendon injuries. In addition to bone regeneration, the aim of our research group is to better understand tendon regeneration and thus to develop improved therapies for patients in the future.

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Featured Pubications

  • Borcherding K, Marx D, Gätjen L, Specht U, Salz D, Thiel K, Wildemann B, Grunwald I

    Impact of Laser Structuring on Medical-Grade Titanium: Surface Characterization and In Vitro Evaluation of Osteoblast Attachment

    A laser treatment to structure standard titanium alloy implants for improved osteointegration offers meaningful potential for orthopedic implants. The objective of this study was to characterize the pore structure shape, treatment‐related metallographic changes, cytocompatibility, and attachment of osteoblast‐like cells (MG‐63).The pore dimensions were a bottleneck diameter of 27 μm, an inner pore width of 78 μm, and a pore depth of 129 μm. The introduced energy of the laser changed the metallic structure of the alloy within the heat‐affected region (approximately 66 μm) without any indication of a micro cracking formation. Cell viability was improved on the structured surface compared to pure titanium, indicating good cytocompatibility.

    Materials (Basel) 2020; 13(8)

  • Fleischhacker V, Klatte-Schulz F, Minkwitz S, Schmock A, Rummler M, Seliger A, Willie BM, Wildemann B

    In Vivo and In Vitro Mechanical Loading of Mouse Achilles Tendons and Tenocytes-A Pilot Study

    Mechanical force is a key factor for the maintenance, adaptation, and function of tendons. Investigating the impact of mechanical loading in tenocytes and tendons might provide important information on in vivo tendon mechanobiology. Therefore, the study aimed at understanding if an in vitro loading set up of tenocytes leads to similar regulations of cell shape and gene expression, as loading of the Achilles tendon in an in vivo mouse model. This study showed that the gene expression of tendon markers was similar, whereas significant changes in cell shape and the expression of extracellular matrix (ECM) related genes were detected between in vivo and in vitro loading.
    This first pilot study is important for understanding to which extent in vitro stimulation set-ups of tenocytes can mimic in vivo characteristics.

    Int J Mol Sci 2020; 21(4)

Results 1 to 10 of total 108

Results 1 to 10 of total 108