Angiogenesis and Immunomechanics
Healing begins with the self-organisation of cells in the wound to reestablish structured tissue and restore the mechanical stability and intrinsic pretension of the injured matrix lost through the injury. Our aim is to decipher this independent organisation of fibroblasts, vascular precursors, immune cells and mechanical instability in the complex environment of the tissue. A better understanding of this interplay forms the basis for novel therapeutic approaches in musculoskeletal regeneration.
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Fracture healing is in part similar to processes of skeletal development and, like these, is also controlled by mechanical stimuli. The formation of vessels is also clearly mechano-biologically controlled. The development of a functional vascular network and the supply of nutrients and proteins as well as the immigration of cells from the blood is essential for any regeneration process. Nevertheless, surprisingly little is known about the mechanisms of supply and consumption during regeneration. Using the example of successful vs. delayed bone healing we try to show the essential elements of metabolism and put them into the context of regenerating microcirculation. Apparently, local mechanical stimuli as well as the local immune response are essential for both metabolic cascades and the formation of new vessels. However, their interplay is largely unknown.