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Angiogenesis and Immunomechanics

Healing begins with the self-organisation of cells in the wound to reestablish structured tissue and restore the mechanical stability and intrinsic pretension of the injured matrix lost through the injury. Our aim is to decipher this independent organisation of fibroblasts, vascular precursors, immune cells and mechanical instability in the complex environment of the tissue. A better understanding of this interplay forms the basis for novel therapeutic approaches in musculoskeletal regeneration.

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3D bioprinting of a vascular network

The aim of the project is to develop a 3D bioprinting strategy to control the architecture of the construct and the precise placement of cells. By specifying certain structures and cell distribution, the formation of a vascularized network within a hydrogel construct is enabled and regulated.

3D bioprinting for the development of a vascularized construct for the investigation of biomechanical processes of angiogenesis

Image of a 3D printed construct after 7 days of cultivation with a confocal microscope. The printed cells formed a pronounced vascular network after this time. Green=CD31; Red=F-actin; Blue=Nuclei

Vascularization is one of the biggest challenges in tissue engineering and regenerative medicine and the production of functional vascularized 3D constructs is of great interest in research. The 3D bioprinting strategy used here, developed jointly with our cooperation partner Cellbricks GmbH, allows us to control the architecture of the construct in the micro range. In addition, this system enables the printing of living cells and their exact placement and distribution. This enables and controls the formation of a vascularized network within a hydrogel construct. This 3D bioprinting approach offers the possibility to precisely and systematically investigate various parameters that influence the formation of vascular structures. Through these investigations, we will contribute to a deeper understanding of angiogenesis in a 3D hydrogel and thus optimize the development of scaffolds for clearly defined vascular structures.

In Cooperation with

In Collaboration with

Dr. Lutz Kloke

CEO and Founder of Cellbricks GmbH

Prof. Dr. rer. nat. Holger Gerhardt

Group Leader at the MDC