Julius Wolff Institut (JWI) - Center for Musculoskeletal Biomechanics and Regeneration 

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Angiogenesis and Immunomechanics

Healing begins with the self-organisation of cells in the wound to reestablish structured tissue and restore the mechanical stability and intrinsic pretension of the injured matrix lost through the injury. Our aim is to decipher this independent organisation of fibroblasts, vascular precursors, immune cells and mechanical instability in the complex environment of the tissue. A better understanding of this interplay forms the basis for novel therapeutic approaches in musculoskeletal regeneration.

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International bridges of cutting-edge research

At the Julius Wolff Institute, we work closely with many national and international scholars in the most diverse fields of musculoskeletal research. These scientific and personal connections have resulted in three bridges of top-level research with Harvard University, ETH Zurich and Oxfort University.

Boston - Berlin: Local Immunmodulation

David Mooney - Wyss Institute of Harvard University - Einstein Visiting Fellow at the JWI

David Mooney looks nature into the cards: the bioengineer from the Harvard School of Engineering and Applied Sciences is investigating how the cells of mammals react to the signals of their environment. On this basis, he is developing novel biomaterials for cell and tissue technology. As an Einstein Visiting Fellow, he was able to provide important impulses in the fields of biotechnology, immunology and the therapy of diseases of the musculoskeletal system.

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Georg Duda - Associate Faculty Member if the Wyss Institute in Boston

Georg Duda has been appointed a Wyss Associate Faculty member. This partnership will help to capitalize upon the engineering and technology translation capabilities of the Wyss Institute more effectively and more broadly. This partnership can deliver new technologies and therapies into the hands of doctors and patients much more quickly than if they would operated alone.

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Zürich - Berlin: Sense cell mechanics

Viola Vogel - ETH Zurich - BIH Einstein Visiting Fellow at the JWI

In proof-of-concept studies, physicist Viola Vogel discovered many mechanisms by which cells use proteins as mechanical-chemical switches. The appreciation of proteins also from their mechanical design and how protein stretching affects physiological and regenerative healing processes is the focus of her ongoing research at ETH Zurich. As an Einstein BIH Visiting Fellow, she works closely with the JWI on the translation of these mechanobiological concepts into clinical practice.

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Oxford - Berlin: Quantitative Regenerative Medicine

Georg Duda - Visiting Professor an der University of Oxford

Georg Duda was appointed Visiting Professor of Regenerative Medicine and Musculoskeletal Sciences by the University of Oxford on 14th November 14 2018. With this award, the British elite university wants to expand and further develop the close cooperation between the Berlin Charité and Oxford in the research field of regenerative therapies. At its core is a closer cooperation with the chair of Prof. Dr. Andrew Carr in the field of controlling inflammatory processes in the regeneration of ligament and other soft tissue injuries.