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Computational Mechanobiology

Tissues in the musculoskeletal system are exquisitely designed with superb mechanical properties. The tissues are also able to adapt to withstand changing mechanical conditions. The Computational Mechanobiology Group is focused on understanding these two exciting features. Using computer modeling techniques, we seek to understand the mechanical behavior of tissues and their adaptive and regenerative response to mechanical stimuli at the different time and length scales.

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Adaptation of basic knowledge to the clinical field

We seek to determine the mechanical behavior of tissues like bone, tendons or muscle and how they adapt their structure to changing loading conditions. In addition, we investigate how these tissues regenerate and how the process is influenced by mechanical and biological constraints. Our goal is to translate basic knowledge on the behavior of healthy, injured and adapted/regenerated tissues to the clinical field. Clinical applications include the design of fixation devices (e.g. for bone fracture healing), prosthesis (e.g. total knee and hip replacements) or drug treatment (e.g. for osteporosis).