Tissues in the musculoskeletal system are exquisitely designed with superb mechanical properties. The tissues are also able to adapt to withstand changing mechanical conditions. The Computational Mechanobiology Group is focused on understanding these two exciting features. Using computer modeling techniques, we seek to understand the mechanical behavior of tissues and their adaptive and regenerative response to mechanical stimuli at the different time and length scales.
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Bone Adaptation to Mechanical Loading
Bone is able to adapt to the mechanical loads placed on it, by adding or removing matrix. We are interested in understanding how local mechanical signals within the bone regulate the local resorption and apposition of bone matrix. To achieve this, we use finite element techniques in combination with novel in vivo microCT image registration methods to correlate the local strain environment to formation and resorption events.
- Authors:Razi H, Birkhold AI, Weinkamer R, Duda GN, Willie BM, Checa SJournal:J Bone Miner Res Year:2015; Volume:30Issue:(10):Pages:1864-73.
- Authors:Birkhold AI, Razi H, Weinkamer R, Duda GN, Checa S, Willie BM
Journal:Bone Year:2015; Volume:75:Pages:210-21.
Title:Monitoring in vivo (re)modeling: a computational approach using 4D microCT data to quantify bone surface movements
- Authors:Razi H, Birkhold AI, Zaslansky P, Weinkamer R, Duda GN, Willie BM, Checa S
Journal:Acta Biomater Year:2015; Volume:13:Pages:301-10.
Title:Skeletal maturity leads to a reduction in the strain magnitudes induced within the bone: a murine tibia study
- Authors:Razi H, Birkhold AI, Zehn M, Duda GN, Willie BM, Checa S
Journal:In: Facta Universitatis Series: Mechanical Engineering Year:2014; Volume:12Issue:(3)
Title:A finite element model of in vivo mouse tibial compression loading: Influence of boundary conditions
- Authors:Birkhold AI, Razi H, Duda GN, Weinkamer R, Checa S, Willie BMJournal:Biomaterials Year:2014; Volume:35Issue:(34):Pages:9290-301.
- Authors:Birkhold AI, Razi H, Duda GN, Weinkamer R, Checa S, Willie BM
Journal:Bone Year:2014; Volume:66:Pages:15-25.
Title:Mineralizing surface is the main target of mechanical stimulation independent of age: 3D dynamic in vivo morphometry
- Authors:Willie BM, Birkhold AI, Razi H, Thiele T, Aido M, Kruck B, Schill A, Checa S, Main RP, Duda GN
Journal:Bone Year:2013; Volume:55Issue:(2):Pages:335-46.
Title:Diminished response to in vivo mechanical loading in trabecular and not cortical bone in adulthood of female C57Bl/6 mice coincides with a reduction in deformation to load