Computational Mechanobiology
Tissues in the musculoskeletal system are exquisitely designed with superb mechanical properties. The tissues are also able to adapt to withstand changing mechanical conditions. The Computational Mechanobiology Group is focused on understanding these two exciting features. Using computer modeling techniques, we seek to understand the mechanical behavior of tissues and their adaptive and regenerative response to mechanical stimuli at the different time and length scales.
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Mechano-Biological Optimization of Scaffolds
Bone regeneration is influenced by the local mechanical and biological environments. We develop computer models to understand the process of tissue regeneration within tissue engineering constructs and apply mechano-biological knowledge to design scaffolds that would promote bone tissue formation in vivo.
Publications
- Authors:Razi H, Checa S, Schaser KD, Duda GN
Journal:J Biomed Mater Res B Appl Biomater Year:2012; Volume:100Issue:(7):Pages:1736-45.
Title:Shaping scaffold structures in rapid manufacturing implants: a modeling approach toward mechano-biologically optimized configurations for large bone defect - Authors:Khayyeri H, Checa S, Tägil M, O'Brien FJ, Prendergast PJ
Journal:J Mater Sci Mater Med Year:2010; Issue:(8)
Title:Tissue differentiation in an in vivo bioreactor: in silico investigations of scaffold stiffness. - Authors:Checa S, Prendergast PJ
Journal:J Biomech Year:2010; Volume:43Issue:(5)
Title:Effect of cell seeding and mechanical loading on vascularization and tissue formation inside a scaffold: a mechano-biological model using a lattice approach to simulate cell activity. - Authors:Sandino C, Checa S, Prendergast PJ, Lacroix D
Journal:Biomaterials Year:2010; Volume:31Issue:(8)
Title:Simulation of angiogenesis and cell differentiation in a CaP scaffold subjected to compressive strains using a lattice modeling approach.