Das Bild zeigt rechts ein Trichterglas mit blauer Flüssigkeit und Glasstab zum Umrühren. Daneben steht ein Reagenzglasständer mit Reagenzgläsern, die ebenfalls blaue Flüssigkeit enthalten. Im Hintergrund ist ein Forscher zu sehen, der in der rechten Hand eine Pipette hält.

Development of combined in-vivo diagnostics

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Towards in-vivo monitoring and stimulation of early callus formation by quantitative focused ultrasound

Cooperation with the Center for Musculoskeletal Surgery and Paris

The aim of this project is the development of a quantitative ultrasound (QUS) based, non-invasive, non-ionising tool for in-vivo monitoring and stimulation of early callus formation in a rat osteotomy model. After in-vitro measurements, 3D micro-elastic models of the osteotomy region will be developed. These models will be used for in-silico sound propagation simulations through the osteotomy gap. Acoustic stimulation levels and sequences required for osteogenic determination of mesenchymal stem cells will be determined in-vitro in cell cultures. The long term goals are to apply this method in small animal bone healing studies and to translate this combined diagnostic/therapeutic concept to the clinical setting.


Publication of the project: Preininger B, Hesse B, Rohrbach D, Varga P, Gerigk H, Langer M, Peyrin F, Perka C, Raum K. Histogram feature-based classification improves differentiability of early bone healing stages from micro-computed tomographic data. J Comput Assist Tomogr. 2012 Jul;36(4):469-76.