The Julius Wolff Institut was instrumental for the development and establishment of several research networks. Beside basic research, these networks join also translation reserach activities for the clinical practice. The networks focus their reserach activities on
- Musculoskeletal Disease and Disorders
- Regenerative Therapies
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DFG Collaborative Research Centre 1444 - Directed Cellular Self‐Organisation to Advance Bone Regeneration
This Collaborative Research Centre aims to unravel the basic mechanisms that differentiate between success and failure in regeneration of musculoskeletal tissue using bone healing as a role model. Bone represents one of the very few tissues in the body that has an intrinsic capability of scar free healing. bone acts at the interface between mechanical stability and the immuneand metabolic balance from the molecular to the tissue level.
Bone Healing as a Model System
The Research Unit aims to understand the basic mechanisms of endogenous regeneration. It focuses in particular on the early immune response and the re-constitution of the mechanical competence with regard to aging. Bone serves a model system because it is one of the few tissues in our body that heals without any scar formation and is therefore capable to completely restore its form and function.
Research Network Osteoarthrosis – OVERLOAD-PrevOp
Mechanically Induced Osteoarthrosis
Overload-PrevOp aims to understand the early stages of mechanically induced osteoarthrosis and modulated in ordert to develop preventative strategies. By combining epidemiological and interventioanl studies, molecular and imaging markers are validated in order to earlyier identify patients at risk. With the help of preclinical sudies and computational validation methods, it will be investigated if the joint loading can be mudulated early on to slow down or even stop the progression of osteoarthrosis.
Muskuloskeletal Cell Therapy
HIPGEN aims at bringing the first regenerative therapy for improving recovery following a surgically treated injury to market approval. The major focus of the HIPGEN are patients undergoing to total or hemiarthoplasty after hip fracture. A multi-center phase III clinical study with 240 patients will be perfomed to determine the efficacy, safety and tolerability of allogeneic PLX-PAD cells to improve recovery following arthroplasty for hip fracture.
The BCRT is an interdisciplinary research center dedicated to improving our understanding of endogenous healing processes in order to develop new diagnostics and treatments. Its research focus is on the study of disorders affecting the immune, musculoskeletal and cardiovascular systems. Researchers are supported with regard to business development, regulatory affairs and health economics very early on in the project to ensure that results are quickly translated into clinical practice.
Berlin-Brandenburg School for Regenerative Therapies (BSRT)
The Berlin-Brandenburg School for Regenerative Therapies (BSRT) promotes the interdisciplinary research and education of doctoral candidates in biology, immunology, engineering and material sciences. The program provides comprehensive knowledge of cell and molecular biology, bioengineering, biotechnology and biomaterials and it also offer key qualifications in areas such as scientific presentation and writing skills, and provides training in clinical studies, economic aspects, and career planning.
Einstein Center for Regenerative Therapies (ECRT)
The ECRT aims to bring together Berlin's researcher who work in the field of Regenerative Therapies. In the competition for the best ideas, Einstein Kickboxes are awarded in order to provide particularly early career scientists with the opportunity to develop their own research concepts. Researcher are given BioThinking support throughout the project development, an innovative approach to problem-solving in interdisciplinary teams that uses Design Thinking in biomedical research.