Joint Loading & Musculoskeletal Analysis
The loads acting in joint prostheses and other orthopaedic implants is still partially unknown. The acting loads are required for different purposes.
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Bone fractures, ligament and tendon ruptures, and muscle lesions occur frequently and in varying degrees of severity. The regeneration of these tissue structures represents a normal physiological process. However, in some cases conservative or surgical intervention is needed. The recovery of function and structural integrity in musculoskeletal tissues after traumatic injuries can be enhanced by pharmacological, cell-therapeutic, and/or mechano-biological means. The goal is to create an advantageous effect on cell proliferation and differentiation for rapidly adapting, functionally effective tissue systems. The impact of such support measures are quantitatively recorded and evaluated by imaging techniques, functional analyses, and computational methods. An improvement of regeneration by cell therapy for muscle trauma or mechano-biological fixation for bone healing has been detected, for instance studies show beneficial results for adapted plate working length to the specific fracture type and geometry. Through detailed knowledge of mechano-biological interactions of various tissue systems, regeneration post trauma could be further improved and also be facilitated for critical injuries or for patients with reduced biological regenerative capacity. In addition to determining cell biological parameters, the quantitative detection of loading and movement of the musculo-skeletal tissue structures is needed to assess the mechano-biologic interactions of cells and their environment in the process of regeneration (Bone Healing and Cell Biology Team JWI).
- Authors:Heyland M, Deppe D, Reisener MJ, Damm P, Taylor WR, Reinke S, Duda GN, Trepczynski AJournal:Front Bioeng Biotechnol. Year:2023;
- Authors:Muellner M, Kreutzinger V, Becker L, Diekhoff T, Pumberger M, Schömig F, Heyland M, Ziegeler K
Journal:Diagnostics (Basel) Year:2022; Volume:12Issue:(2)
Title:Unexpected Sex Differences in the Relationship of Sacroiliac Joint and Lumbar Spine Degeneration
- Authors:Rau D, Rußow G, Heyland M, Wulsten D, Kösters C, Schmölz W, Märdian SJournal:J Clin Med Year:2022; Volume:11Issue:(3)
- Authors:Keltz E, Mora AJ, Wulsten D, Rußow G, Märdian S, Duda GN, Heyland MJournal:Injury Year:2021; Volume:52Issue:(6)
- Authors:Osterhoff G, Wulsten D, Babu S, Heyland M, Pari C
Journal:Eur J Trauma Emerg Surg Year:2021; Volume:47Issue:(5):Pages:1307-1312.
Title:Antegrade versus retrograde screw fixation of anterior column acetabular fractures: a biomechanical in vitro study
- Authors:Märdian S, Schmölz W, Schaser KD, Duda GN, Heyland M
Journal:Clin Biomech (Bristol, Avon) Year:2019; Volume:70:Pages:89-96.
Title:Locking plate constructs benefit from interfragmentary lag screw fixation with decreased shear movements and more predictable fracture gap motion in simple fracture patterns
- Authors:Heyland M, Checa S, Kendoff D, Duda GN
Journal:Sci Rep Year:2019; Volume:9Issue:(1):Pages:482.
Title:Anatomic grooved stem mitigates strain shielding compared to established total hip arthroplasty stem designs in finite-element models
- Authors:Rendenbach C, Steffen C, Sellenschloh K, Heyland M, Morlock MM, Toivonen J, Moritz N, Smeets R, Heiland M, Vallittu PK, Huber G
Journal:J Mech Behav Biomed Mater Year:2019; Volume:91:Pages:212-219.
Title:Patient specific glass fiber reinforced composite versus titanium plate: A comparative biomechanical analysis under cyclic dynamic loading
- Authors:Heyland MJournal:J Invest Surg Year:2018; Volume:32Issue:(3):Pages:255-256.
- Authors:Heyland M, Duda GN, Mardian S, Schutz M, Windolf MJournal:Unfallchirurg Year:2017; Volume:120Issue:(2):Pages:103-109.