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The formation of new blood vessels and the tight regulation of inflammation are essential during the initial phase of bone healing. Disturbances of the early healing cascade can result in delayed healing or non-union of fractures.
Within this project different peripheral blood cell populations were considered and analyzed for their ability to counterbalance exaggerated inflammation and to locally support angiogenesis at the fracture site. Concentrating on the versatile CD31+ cell population that contains a mixture of cells (e.g. monocytes, naïve B- and T-cells, endothelial precursors) with diverse regenerative properties, we are now developing a cell therapeutic approach that can be applied within the operation theater during initial fracture treatment.