Computational Mechanobiology

Tissues in the musculoskeletal system are exquisitely designed with superb mechanical properties. The tissues are also able to adapt to withstand changing mechanical conditions. The Computational Mechanobiology Group is focused on understanding these two exciting features. Using computer modeling techniques, we seek to understand the mechanical behavior of tissues and their adaptive and regenerative response to mechanical stimuli at the different time and length scales.

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Bone Remodeling around Implants

Periprosthetic bone loss remains a persistent concern in the long term survival of primary total hip arthroplasty (THA). Changes in the loading conditions, geometry and material properties after THA alter the internal mechanical environment within the bone, stimulating a periprosthetic bone remodelling response which usually leads to a net bone loss. This is of major concern, particularly in the proximal Gruen zones, which are critical for implant stability and Iongevity. Using computer modeling techniques, we investigate the mechanics of total hip replacement and explore the limits of current designs.

Computer model predictions of bone remodeling around two different hip implant designs. Differences in bone density of the remodeled and intact bone are plotted for different mechanical strain thresholds leading to formation and resorption responses.