Knee joint replacement

Dr.-Ing. Philippe Moewis

Despite improvements on knee joint replacements in the last years, there are still patients with problems regarding their implants. By using analyzes and models, we want to help enabling patients to live a normal life.

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Despite the unquestionable improvements and the success of total knee arthroplasty (TKA) over the last decades, a substantial number of patients remain unsatisfied with the outcome. Over 20% of patients report persisting knee pain without distinct radiological evidence or clinical rationale. It remains under debate if altered physiological knee kinematics developed after TKA are specifically responsible for this dissatisfaction. Additionally, the patients’ desire to return to activities of daily living and participation in sports make TKA implant optimization necessary.

In order to provide valuable information to surgeons and implant manufacturers about the postoperative performance of TKA implants, single plane fluoroscopy analysis is conducted during unloaded and loaded knee flexion activities. This technique accurately quantifies 3D knee joint kinematics and allows clear insight into the behavior of the analyzed implant. Gait analysis is also conducted to give an overview of the knee joint kinematics during daily activities (compare ‘Functional Adaptation’).

Moreover, the information collected from this analysis, when combined with specific in vivo load data and geometrical characteristics can be used as inputs for finite element (FE) analysis. This multi-pronged analysis allows for in-depth assessments of implant performance before implementation in the market.

Running Projects

  • "Joint Research Project: Understanding and Prevention of primary Osteoarthritis progression (OVERLOAD-PrevOP) financed by Federal Ministry of Education and Research, Support Code 01 EC1408A
  • "Development of a knee endoprosthesis design with an anatomical joint line for the international market". Zentrales Innovationsprogramm Mittelstand (ZIM) Project Code KF2744003AK3
  • "Kinematic Analysis: In-vivo comparison of different levels of femoral rollback in a mobile bearing, cruciate retaining Primary Total Knee Arthroplasty". HCC Reference Number: GOFSO00275/ICD Number: 662411

Clinical Partners

  • Univ.-Prof. Dr. med. Carsten Perka, Medical Director, Center for Musculoskeletal Surgery, CharitéUniversitätsmedizin Berlin.
  • Dr. med. Tilman Pfitzner, Managerial Attending Physician (Geschäftsführender Oberarzt), Center for Musculoskeletal Surgery, CharitéUniversitätsmedizin Berlin.
  • Dr. med. Philipp von Roth, Medical Specialist (Facharzt), Center for Musculoskeletal Surgery, CharitéUniversitätsmedizin Berlin.

Industry Partners

  • DePuy Synthes, Warsaw, Indiana, USA
  • OHST Medical Technology, Rathenow, Brandenburg, Germany

Scientific Partners

  • Prof. Dr. William R. Taylor, Institute for Biomechanics, ETH Zurich, Switzerland