Regeneration post Trauma

Dipl.-Ing. Mark Heyland

Learn more about our projects regarding regeneration after trauma.

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Bone fractures, ligament and tendon ruptures, and muscle lesions occur frequently and in varying degrees of severity. The regeneration of these tissue structures represents a normal physiological process. However, in some cases conservative or surgical intervention is needed. The recovery of function and structural integrity in musculoskeletal tissues after traumatic injuries can be enhanced by pharmacological, cell-therapeutic, and/or mechano-biological means. The goal is to create an advantageous effect on cell proliferation and differentiation for rapidly adapting, functionally effective tissue systems. The impact of such support measures are quantitatively recorded and evaluated by imaging techniques, functional analyses, and computational methods. An improvement of regeneration by cell therapy for muscle trauma or mechano-biological fixation for bone healing has been detected, for instance studies show beneficial results for adapted plate working length to the specific fracture type and geometry. Through detailed knowledge of mechano-biological interactions of various tissue systems, regeneration post trauma could be further improved and also be facilitated for critical injuries or for patients with reduced biological regenerative capacity. In addition to determining cell biological parameters, the quantitative detection of loading and movement of the musculo-skeletal tissue structures is needed to assess the mechano-biologic interactions of cells and their environment in the process of regeneration (Bone Healing and Cell Biology Team JWI).

Running projects:

  • Functional regeneration after muscle trauma aided by allogenic cell therapy: A study in total hip replacement patients, supported by Pluristem Inc. and by a grant from the German federal Ministry of Education and Research and the Berlin-Brandenburg Center for Regenerative Therapies (BCRT).
  • Evaluation of Locking Screw plate fixation using a computer based biomechanical approach (Improvement of mechano-biological fixation)
  • Evaluating the Position and Orientation of Osteosynthesis Implants from Conventional 2D X-ray Images

Clinical partners:

  • Dr. med. Sven Märdian, Attending Physician (Oberarzt), Center for Musculoskeletal Surgery, Charité Universitätsmedizin Berlin
  • Dr. med. Tobias Winkler, Specialist (Facharzt), Center for Musculoskeletal Surgery, Charité Universitätsmedizin Berlin

Industry partners:

  • DePuy Synthes, Zuchwil, Switzerland
  • Pluristem Therapeutics Inc., Haifa, Israel

Scientific partners:

  • Moritz Ehlke, Dr. Stefan Zachow, (Zuse Institut Berlin)
  • Prof. Dr. med. Dankward Höntzsch, Dr. med. Stefan Döbele, (Berufsgenossenschaftliche Unfallklinik Tübingen)
  • Prof. Dr. Werner Schmölz, (Head of Biomechanics, Department of Trauma Surgery, Innsbruck Medical University)