Tendon and Bone Regeneration

Bones represent the supporting structure of the body, whereas the tendons allow our movement by transferring forces from the muscle to the bone. About 20% of all medical consultations are in the musculoskeletal area, of which about 30% are associated with tendon injuries. In addition to bone regeneration, the aim of our research group is to better understand tendon regeneration and thus to develop improved therapies for patients in the future.

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Featured Pubications

  • Klatte-Schulz F, Minkwitz S, Schmock A, Bormann N, Kurtoglu A, Tsitsilonis S, Manegold S, Wildemann B

    Different Achilles Tendon Pathologies Show Distinct Histological and Molecular Characteristics


    The aim of the present study was to characterize different acute and chronic Achilles tendon disorders. Achilles tendon samples from patients with chronic tendinopathy (n = 7), chronic ruptures (n = 6), acute ruptures (n = 13), and intact tendons (n = 4) were analyzed. The study gives an insight into structural and molecular changes of pathological processes in tendons and might be used to identify targets for future therapy of tendon pathologies.

    Int J Mol Sci 2018; 19(2)

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  • Huber E, Pobloth AM, Bormann N, Kolarczik N, Schmidt-Bleek K, Schell H, Schwabe P, Duda GN, Wildemann B

    (*) Demineralized Bone Matrix as a Carrier for Bone Morphogenetic Protein-2: Burst Release Combined with Long-Term Binding and Osteoinductive Activity Evaluated In Vitro and In Vivo


    To allow bone defect regeneration, autologous bone grafting still represents the gold standard. However, autograft harvesting has limitations, including an additional surgery, donor site morbidity, and limited availability. Demineralized bone matrix (DBM) would represent an alternative, yet lacks sufficient osteoinductive properties. Combining DBM with a potent agent, such as bone morphogenetic protein-2 (BMP-2) might be a feasible alternative approach, optimizing an established grafting material with strong osteoinductive properties.

    Tissue Eng Part A 2017; 23(23-24):1321-1330.

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Results 1 to 10 of total 93


Results 1 to 10 of total 93