Translational Research Projects

With our research for the clinicial practice in orthopedics and trauma surgery we improve patient care and creat innovations for implants for joint replacements and to support fracture healing. Through a better understanding of biological processes during healing, we develop new therapies and products for accelerating healing processes. In order to translate our findings into clinicial practice we closely collaborate with national and international partners in industry and academia.

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Translational Projects - Therapy

Musculoskeletal Advanced Therapy

HIPGEN - A Multicenter Phase III Trial

HIPGEN aims at bringing the first regenerative therapy for improving recovery following a surgically treated injury to market approval. The major focus of the HIPGEN are patients undergoing to total or hemiarthoplasty after hip fracture. A multi-center phase III clinical study with 240 patients will be perfomed to determine the efficacy, safety and tolerability of allogeneic PLX-PAD cells to improve recovery following arthroplasty for hip fracture.

Translational Projects - Diagnostic

Diagnosis of bone healing impairments

Development of a rapid diagnostic test kit

In 5-15% of the patients bone healing is delayed or does not heal at all. There is currently no prognostic tool available to predict the healing outcome at an early stage. Currently, we perform a prospective clinical valisation study of CD8+TEMRA cells als preoperative prognostic biomarker for the prediction of the fracture healing outcome. This will enable the decision-making about necessary additive therapies such as the application of growth factors or suitable cell therapies which are unsuitable for routine applications.

Lower back pain diagnosis

Around-the-clock measurements of spinal shape and motion

We developed and validated diagnostic devices that enable measurements of spinal posture, shape and motion during daily activities. These measurement devices are wireless, portable and allow long-term measurements for up to 24 hours without restrictions for the patient. As a result, our functional analysis allows a more comprehensive diagnosis of low back pain patients then current clinical diagnostic approaches. It has also the advantage that patients are not exposed to any radiation.

Diagnosis of in vivo acting loads

OrthoLoadLab

Aim of the OrthoLoadLab is the direct translation of science and research into industrial development and clinical application. Producs from local medical technology companies will be analysed with respect to loads and function and new product developments will be optimised with regard to physiological requirements in order to increas the safety of endoprosthesis products. Beside the analysis of the clinical outcome and functionality, access is given to a worlwide unique scientifically profound data collection which provides robust information for industrial product development. 

Translational Projects - Prevention

Biomechanical gait and running analysis

RunScan 

RunScan is a biomechanical analysis for gait and running offered by the JWI. Based on a thorough initial medical check and with modern analytical methods, we evaluate the gait and running characteristics of patients as well as hobby and professional athletes. During the examination of the running technique, we consider the biomechanical aspects of the entire body of the investigated person with regard to the latest research findings. Thus, we can identify errors in the movement pattern, recognise causes of pain and injuries in the musculoskeletal system and uncover shortcomings in the running techniques.