Publications

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Selected publications

Hydrogels with tunable stress relaxation regulate stem cell fate and activity.

Chaudhuri O, Gu L, Klumpers D, Darnell M, Bencherif SA, Weaver JC, Huebsch N, Lee HP, Lippens E, Duda GN, Mooney DJ.

Nat Mater. 2016 Mar; 15(3): 326-334. doi:10.1038/NMAT4489

This paper describes the use of stress relaxation as a design parameter for materials in tissue engineering, particularly in the context of regulating cell proliferation and promoting bone regeneration.

MicroCT analysis of bone regeneration in rat cranial defects due to hMSC transplanted in void-forming hydrogels with different bulk-component elastic moduli.

Matrix elasticity of void-forming hydrogels controls transplanted-stem-cell-mediated bone formation.

Huebsch N, Lippens E, Lee K, Mehta M, Koshy ST, Darnell MC, Desai RM, Madl CM, Xu M, Zhao X, Chaudhuri O, Verbeke C, Kim WS, Alim K, Mammoto A, Ingber DE, Duda GN, Mooney DJ.

Nat Mater. 2015 Dec; 14(12):1269-1277. doi: 10.1038/nmat4407.

Stem cell behavior can be controlled in vitro by manipulating the elasticity of materials, yet therapeutic translation remains elusive. We show by developing injectable, void-forming hydrogels, that MSC osteogenesis and cell deployment, can be controlled by modifying, resp., the hydrogels elastic modulus or its chemistry. 

Representative H&E staining images of samples harvested from the cranial defects of rats: example of new bone centering around CPC residues for group 1,

Bone regeneration via novel macroporous CPC scaffolds in critical-sized cranial defects in rats.

Lee K*, Weir MD*, Lippens E*, Mehta M, Wang P, Duda GN, Kim WS, Mooney DJ, Xu HH.

Dent Mater. 2014 Jul;30(7):e199-207. doi: 10.1016/j.dental.2014.03.008.

The objective of this study was to investigate bone regeneration via novel macroporous calcium phosphate cement (CPC) containing absorbable fibers, hydrogel microbeads and growth factors injected in critical-sized cranial defects in rats. In comparison to traditional CPC the macroporous CPCs showed new bone up to 2-fold that of traditional CPC control at 4 weeks, and 3-fold that at 24 weeks, and hence may be useful for dental, craniofacial and orthopedic applications.

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