Matrix physical properties play an important role in regeneration and disease. We control biomaterial physical properties, such as geometry, stiffness or degradation properties, to modulate cell response and tissue regeneration in-vivo. The hierarchical material structure of newly formed tissue is investigated at multiple length scales.
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Patterned hydrogel degradation to guide cellular response, matrix deposition and in-vivo tissue regeneration
In this project we aim to direct cell migration, matrix deposition and its microstructure through spatial and temporal control of degradation properties of click alginate hydrogels. The ultimate goal is to guide in-vivo tissue regeneration through controlled hydrogel degradation.
Alginate void-forming hydrogels for in-vivo cell recruitment and differentiation
Alginate void-forming hydrogels, with mechanical properties optimized to induce osteogenic cell differentiation, were supplemented with mesenchymal stem cells to attract endogenous cells to the defect site via paracrine effects. The influence of the immune system was investigated using immune compromised vs. immune competent in-vivo models.