Mechano-Biological Optimization of Scaffolds

Univ.- Prof. Dr. Sara Checa Esteban

Learn more about our research area mechano-biological optimization of scaffolds.

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Mechanical strains within bone tissue scaffolds of different configurations leading to different mechanical environments within the construct.

Bone regeneration is influenced by the local mechanical and biological environments. We develop computer models to understand the process of tissue regeneration within tissue engineering constructs and apply mechano-biological knowledge to design scaffolds that would promote bone tissue formation in vivo.

Publications

Razi H, Checa S, Schaser KD, Duda GN. (2012) Shaping scaffold structures in rapid manufacturing implants: a modeling approach toward mechano-biologically optimized configurations for large bone defect. J Biomed Mater Res B Appl Biomater.; 100(7):1736-45.

Khayyeri H, Checa S, Tägil M, O'Brien FJ, Prendergast PJ. (2010). Tissue differentiation in an in vivo bioreactor: in silico investigations of scaffold stiffness. J Mater Sci Mater Med. 2010 Aug;21(8):2331-6.

Checa S, Prendergast PJ. (2010) Effect of cell seeding and mechanical loading on vascularization and tissue formation inside a scaffold: a mechano-biological model using a lattice approach to simulate cell activity. J. Biomechanics, 43: 961-8.

Sandino C, Checa S, Prendergast PJ, Lacroix D. (2010) Simulation of angiogenesis and cell differentiation in a CaP scaffold subjected to unconfined compressive strain using a lattice modeling approach. Biomaterials, 31: 2446-2452.