Knochen ist ein sehr interessantes Gewebe, da es zur Regeneration fähig ist, nachdem es eine Verletzung erlitten hat. Trotzdem kommt es auch heute noch und auch bei guter medizinischer Versorgung, bei 5-20% aller Frakturen zu einer für den Patienten unbefriedigenden verspäteten Heilung oder die Heilung bleibt sogar vollständig aus. Für diese Patienten eine sinnvolle Lösungsstrategie zu finden ist Ziel unserer Forschung.

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Ausgewählte Publikationen

  • Bucher C, Schlundt C, Wulsten D, Sass F, Wendler S, Ellinghaus A, Thiele T, Seemann R, Willie B, Volk H, Duda G, Schmidt-Bleek K

    Experience in the Adaptive Immunity Impacts Bone Homeostasis, Remodeling, and Healing

    Bone formation is substantially reduced in aged individual owing to the experience of the adaptive immunity. Thus, immune-aging in addition to chronological aging is a potential risk factor, with an experienced immune system being recognized as more pro-inflammatory. In metaphyseal bone, immune-aging affects bone homeostasis by impacting bone formation capacity and thereby influencing mass and microstructure of bone trabeculae leading to an overall reduced mechanical competence as found in bone torsional testing. Bone formation is impacted during bone regeneration in terms of a diminished healing capacity observed in young animals who have an experienced human immune system. Considering the immune system's experience level will likely allow a more effective differentiation (stratify) and treatment (immune-modulate) of patients .

    Front Immunol 2019; 10:797.

  • Lang A, Kirchner M, Stefanowski J, Durst M, Weber MC, Pfeiffenberger M, Damerau A, Hauser AE, Hoff P, Duda GN, Buttgereit F, Schmidt-Bleek K, Gaber T

    Collagen I-based scaffolds negatively impact fracture healing in a mouse-osteotomy-model although used routinely in research and clinical application

    Clinical application of bone morphogenetic protein 2 is only approved when applied on an absorbable bovine collagen I scaffold (ACS). Nevertheless, the influence of ACS alone on bone healing remains so far unknown. In vitro studies using ASC-H (Helistat) revealed a suppression of osteogenic differentiation and a reduction of cell vitality compared to ASC-L, another frequently used scaffold. In vivo, a significant delay in bone healing was observed when ACS-L was applied during femoral osteotomy. This negative influence of ACS-H and ACS-L on bone formation demonstraties a substantial need for more sophisticated delivery systems for local stimulation of bone healing.

    Acta Biomater 2019; 86:171-184.


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Ergebnisse 1 bis 10 von insgesamt 63