Knochenheilung
Knochen ist ein sehr interessantes Gewebe, da es zur Regeneration fähig ist, nachdem es eine Verletzung erlitten hat. Trotzdem kommt es auch heute noch und auch bei guter medizinischer Versorgung, bei 5-20% aller Frakturen zu einer für den Patienten unbefriedigenden verspäteten Heilung oder die Heilung bleibt sogar vollständig aus. Für diese Patienten eine sinnvolle Lösungsstrategie zu finden ist Ziel unserer Forschung.
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Ausgewählte Publikationen
Autoren:Bucher C, Schlundt C, Wulsten D, Sass F, Wendler S, Ellinghaus A, Thiele T, Seemann R, Willie B, Volk H, Duda G, Schmidt-Bleek K
Titel:Experience in the Adaptive Immunity Impacts Bone Homeostasis, Remodeling, and Healing
Bone formation is substantially reduced in aged individual owing to the experience of the adaptive immunity. Thus, immune-aging in addition to chronological aging is a potential risk factor, with an experienced immune system being recognized as more pro-inflammatory. In metaphyseal bone, immune-aging affects bone homeostasis by impacting bone formation capacity and thereby influencing mass and microstructure of bone trabeculae leading to an overall reduced mechanical competence as found in bone torsional testing. Bone formation is impacted during bone regeneration in terms of a diminished healing capacity observed in young animals who have an experienced human immune system. Considering the immune system's experience level will likely allow a more effective differentiation (stratify) and treatment (immune-modulate) of patients .
Zeitschrift (Journal):Front Immunol Jahr:2019; Jahrgang (Volume):10:Seiten (Pages):797.
Autoren:Lang A, Kirchner M, Stefanowski J, Durst M, Weber MC, Pfeiffenberger M, Damerau A, Hauser AE, Hoff P, Duda GN, Buttgereit F, Schmidt-Bleek K, Gaber T
Titel:Collagen I-based scaffolds negatively impact fracture healing in a mouse-osteotomy-model although used routinely in research and clinical application
Clinical application of bone morphogenetic protein 2 is only approved when applied on an absorbable bovine collagen I scaffold (ACS). Nevertheless, the influence of ACS alone on bone healing remains so far unknown. In vitro studies using ASC-H (Helistat) revealed a suppression of osteogenic differentiation and a reduction of cell vitality compared to ASC-L, another frequently used scaffold. In vivo, a significant delay in bone healing was observed when ACS-L was applied during femoral osteotomy. This negative influence of ACS-H and ACS-L on bone formation demonstraties a substantial need for more sophisticated delivery systems for local stimulation of bone healing.
Zeitschrift (Journal):Acta Biomater Jahr:2019; Jahrgang (Volume):86:Seiten (Pages):171-184.
Publikationen
- Autoren:Gisbert-Garzarán M, Berkmann JC, Giasafaki D, Lozano D, Spyrou K, Manzano M, Steriotis T, Duda GN, Schmidt-Bleek K, Charalambopoulou G, Vallet-Regí M
Zeitschrift (Journal):ACS Appl Mater Interfaces Jahr:2020;
Titel:Engineered pH-Responsive Mesoporous Carbon Nanoparticles for Drug Delivery - Autoren:Garske DS, Schmidt-Bleek K, Ellinghaus A, Dienelt A, Gu L, Mooney DJ, Duda G, Cipitria A
Zeitschrift (Journal):Tissue Eng Part A Jahr:2020;
Titel:Alginate Hydrogels for In Vivo Bone Regeneration: The Immune Competence of the Animal Model Matters - Autoren:Stefanowski J, Lang A, Rauch A, Aulich L, Köhler M, Fiedler AF, Buttgereit F, Schmidt-Bleek K, Duda GN, Gaber T, Niesner RA Hauser AE1,2.
Zeitschrift (Journal):Front Immunol Jahr:2019; Jahrgang (Volume):10
Titel:Spatial Distribution of Macrophages During Callus Formation and Maturation Reveals Close Crosstalk Between Macrophages and Newly Forming Vessels - Autoren:Schlundt C, Reinke S, Geissler S, Bucher CH, Giannini C, Märdian S, Dahne M, Kleber C, Samans B, Baron U, Duda GN, Volk HD, Schmidt-Bleek K
Zeitschrift (Journal):Front Immunol Jahr:2019; Jahrgang (Volume):10
Titel:Individual Effector/Regulator T Cell Ratios Impact Bone Regeneration - Autoren:Jirkof P, Durst M, Klopfleisch R, Palme R, Thöne-Reineke C, Buttgereit F, Schmidt-Bleek K, Lang A
Zeitschrift (Journal):Sci Rep Jahr:2019; Jahrgang (Volume):9Ausgabe (Issue):(1)
Titel:Administration of Tramadol or Buprenorphine via the drinking water for post-operative analgesia in a mouse-osteotomy model. - Autoren:Sbierski-Kind J, Schmidt-Bleek K, Streitz M, Kath J, Spranger J, Volk H
Zeitschrift (Journal):J Vis Exp Jahr:2019; Jahrgang (Volume):Apr 26;(146). doi: 10.3791/59470
Titel:An Advanced Murine Model for Nonalcoholic Steatohepatitis in Association with Type 2 Diabetes - Autoren:Bucher C, Schlundt C, Wulsten D, Sass F, Wendler S, Ellinghaus A, Thiele T, Seemann R, Willie B, Volk H, Duda G, Schmidt-Bleek K
Zeitschrift (Journal):Front Immunol Jahr:2019; Jahrgang (Volume):10:Seiten (Pages):797.
Titel:Experience in the Adaptive Immunity Impacts Bone Homeostasis, Remodeling, and Healing - Autoren:Wendler S, Schlundt C, Bucher CH, Birkigt J, Schipp CJ, Volk HD, Duda GN, Schmidt-Bleek K
Zeitschrift (Journal):Front Immunol Jahr:2019; Jahrgang (Volume):10:Seiten (Pages):713.
Titel:Immune Modulation to Enhance Bone Healing-A New Concept to Induce Bone Using Prostacyclin to Locally Modulate Immunity - Autoren:Lang A, Kirchner M, Stefanowski J, Durst M, Weber MC, Pfeiffenberger M, Damerau A, Hauser AE, Hoff P, Duda GN, Buttgereit F, Schmidt-Bleek K, Gaber T
Zeitschrift (Journal):Acta Biomater Jahr:2019; Jahrgang (Volume):86:Seiten (Pages):171-184.
Titel:Collagen I-based scaffolds negatively impact fracture healing in a mouse-osteotomy-model although used routinely in research and clinical application - Autoren:Petersen A, Princ A, Korus G, Ellinghaus A, Leemhuis H, Herrera A, Klaumunzer A, Schreivogel S, Woloszyk A, Schmidt-Bleek K, Geissler S, Heschel I, Duda GN
Zeitschrift (Journal):Nat Commun Jahr:2018; Jahrgang (Volume):9Ausgabe (Issue):(1):Seiten (Pages):4430.
Titel:A biomaterial with a channel-like pore architecture induces endochondral healing of bone defects
