Molekulare Unfallchirurgie
Die Arbeitsgruppe Molekulare Unfallchirurgie untersucht die molekularen und zellulären Grundlagen klinisch relevanter Fragestellungen in der muskuloskeletalen Chirurgie mit dem Schwerpunkt auf pharmakologisch verwertbaren Signalereignissen.
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Ausgewählte Publikationen
Autoren:Köhli P, Appelt J, Otto E, Jahn D, Baranowsky A, Bahn A, Erdmann C, Müchler J, Mülleder M, Tsitsilonis S, Keller J
Titel:Effects of CGRP receptor antagonism on glucose and bone metabolism in mice with diet-induced obesity
Our study was designed to characterize the effects of CGRP antagonism on bone and glucose metabolism in a murine model of diet-induced obesity (DIO). A subcutaneous pellet releasing the CGRP receptor antagonist BIBN 4096 (BIBN; olcegepant) was implanted in WT mice with DIO. Metabolic effects were assessed through body- and organ-weights, oral glucose tolerance (oGT), serum lipids, and gene-expression studies. Bone turnover was assessed through histomorphometry of non-decalcified bone sections and analyses of bone turnover markers in serum samples. BIBN treatment did not alter body weight gain or the levels of serum lipids including triacylglycerol and cholesterol during DIO. BIBN led to a moderate improvement of oGT which was accompanied by an increased expression of stearoyl-CoA desaturase in the liver. In skeletal tissue, BIBN treatment resulted in reduced bone volume. This was explained by decreased parameters of bone formation whereas bone resorption was not affected.
Zeitschrift (Journal):Bone Jahr:2021; Jahrgang (Volume):143
Publikationen Serafeim Tsitsillonis
- Autoren:Niemann M, Märdian S, Niemann P, Tetteh L, Tsitsilonis S, Braun KF, Stöckle U, Graef F
Zeitschrift (Journal):PLoS One Jahr:2021; Jahrgang (Volume):16Ausgabe (Issue):(9)
Titel:Transforming the German ICD-10 (ICD-10-GM) into Injury Severity Score (ISS)-Introducing a new method for automated re-coding - Autoren:Weinrich L, Paraskevaidis M, Schleip R, Agres AN, Tsitsilonis S
Zeitschrift (Journal):Life (Basel) Jahr:2021; Jahrgang (Volume):11Ausgabe (Issue):(8)
Titel:Does the Calcaneus Serve as Hypomochlion within the Lower Limb by a Myofascial Connection?-A Systematic Review - Autoren:Baranowsky A, Appelt J, Tseneva K,Jiang S, Jahn D, Tsitsilonis S, Frosch KH, Keller J
Zeitschrift (Journal):Int J Mol Sci Jahr:2021; Jahrgang (Volume):22Ausgabe (Issue):(1)
Titel:Tranexamic Acid Promotes Murine Bone Marrow-Derived Osteoblast Proliferation and Inhibits Osteoclast Formation In Vitro - Autoren:Garbe A, Graef F, Appelt J, Schmidt-Bleek K, Jahn D, Lünnemann T, Tsitsilonis S, Seemann R
Zeitschrift (Journal):Int J Mol Sci Jahr:2020; Jahrgang (Volume):21Ausgabe (Issue):(23)
Titel:Leptin Mediated Pathways Stabilize Posttraumatic Insulin and Osteocalcin Patterns after Long Bone Fracture and Concomitant Traumatic Brain Injury and Thus Influence Fracture Healing in a Combined Murine Trauma Model - Autoren:Maleitzke T, Hildebrandt A, Weber J, Dietrich T, Appelt J, Jahn D, Zocholl D, Baranowsky A, Duda GN, Tsitsilonis S, Keller K
Zeitschrift (Journal):Rheumatology (Oxford) Jahr:2021; Jahrgang (Volume):60Ausgabe (Issue):(4):Seiten (Pages):1996-2009.
Titel:Proinflammatory and bone protective role of calcitonin gene-related peptide alpha in collagen antibody-induced arthritis - Autoren:Baranowsky A, Appelt J, Kleber CH, Lange T, Ludewig P, Jahn D, Pandey P, Keller D, Rose Th, Schetler D, Braumüller S, Huber-Lang M, Tsitsilonis S, Yorgan T, Frosch KH, Amling M, Schinke TH, Keller J
Zeitschrift (Journal):Crit Care Med Jahr:2021; Jahrgang (Volume):49Ausgabe (Issue):(1):Seiten (Pages):e41-e52.
Titel:Procalcitonin Exerts a Mediator Role in Septic Shock Through the Calcitonin Gene-Related Peptide Receptor - Autoren:Köhli P, Appelt J, Otto E, Jahn D, Baranowsky A, Bahn A, Erdmann C, Müchler J, Mülleder M, Tsitsilonis S, Keller J
Zeitschrift (Journal):Bone Jahr:2021; Jahrgang (Volume):143
Titel:Effects of CGRP receptor antagonism on glucose and bone metabolism in mice with diet-induced obesity - Autoren:Otto E, Köhli P, Appelt J, Menzel St, Fuchs M, Bahn A, Graef F, Duda GN, Tsitsilonis S, Keller J, Jahn D
Zeitschrift (Journal):Sci Rep Jahr:2020; Jahrgang (Volume):10Ausgabe (Issue):(1):Seiten (Pages):15057.
Titel:Validation of reference genes for expression analysis in a murine trauma model combining traumatic brain injury and femoral fracture - Autoren:Appelt J, Baranowsky A, Jahn D, Yorgan T, Köhli P, Otto E, Khomeijani Farahani S, Graef F, Fuchs M, Herrera A, Amling M, Schinke TH, Frosch KH, Duda GN, Tsitsilonis S, Keller K
Zeitschrift (Journal):EBioMedicine Jahr:2020; Jahrgang (Volume):59
Titel:The neuropeptide calcitonin gene-related peptide alpha is essential for bone healing - Autoren:Maleitzke T, Plachel F, Fleckenstein FN, Wichlas F, Tsitsilonis S
Zeitschrift (Journal):J Orthop Surg Res Jahr:2020; Jahrgang (Volume):15Ausgabe (Issue):(1):Seiten (Pages):351.
Titel:Haematoma block: a safe method for pre-surgical reduction of distal radius fractures
