Molekulare Unfallchirurgie
Die Arbeitsgruppe Molekulare Unfallchirurgie untersucht die molekularen und zellulären Grundlagen klinisch relevanter Fragestellungen in der muskuloskeletalen Chirurgie mit dem Schwerpunkt auf pharmakologisch verwertbaren Signalereignissen.
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Ausgewählte Publikationen
Autoren:Köhli P, Appelt J, Otto E, Jahn D, Baranowsky A, Bahn A, Erdmann C, Müchler J, Mülleder M, Tsitsilonis S, Keller J
Titel:Effects of CGRP receptor antagonism on glucose and bone metabolism in mice with diet-induced obesity
Our study was designed to characterize the effects of CGRP antagonism on bone and glucose metabolism in a murine model of diet-induced obesity (DIO). A subcutaneous pellet releasing the CGRP receptor antagonist BIBN 4096 (BIBN; olcegepant) was implanted in WT mice with DIO. Metabolic effects were assessed through body- and organ-weights, oral glucose tolerance (oGT), serum lipids, and gene-expression studies. Bone turnover was assessed through histomorphometry of non-decalcified bone sections and analyses of bone turnover markers in serum samples. BIBN treatment did not alter body weight gain or the levels of serum lipids including triacylglycerol and cholesterol during DIO. BIBN led to a moderate improvement of oGT which was accompanied by an increased expression of stearoyl-CoA desaturase in the liver. In skeletal tissue, BIBN treatment resulted in reduced bone volume. This was explained by decreased parameters of bone formation whereas bone resorption was not affected.
Zeitschrift (Journal):Bone Jahr:2021; Jahrgang (Volume):143
Publikationen Serafeim Tsitsillonis
- Autoren:Biedermann L, Bandick E, Ren Y, Tsitsilonis S, Donner S, Müller M, Duda G, Perka C, Kienzle A
Zeitschrift (Journal):JB JS Open Access Jahr:2023; Jahrgang (Volume):8Ausgabe (Issue):(1)
Titel:Inflammation of Bone in Patients with Periprosthetic Joint Infections of the Knee - Autoren:Maleitzke T, ZhouS, Zocholl D, Fleckenstein FN, Back DA, Plewe JM, Weber J, Winkler T, Stöckle U, Tsitsilonis S, Märdian S
Zeitschrift (Journal):Front Immunol Jahr:2023; Jahrgang (Volume):13
Titel:Routine laboratory parameters predict intensive care unit admission and hospitalization in patients suffering stab injuries - Autoren:Duda GN, Geissler S, Checa S, Tsitsilonis S, Petersen A, Schmidt-Bleek K
Zeitschrift (Journal):Nat Rev Rheumatol Jahr:2023; Jahrgang (Volume):19Ausgabe (Issue):(2):Seiten (Pages):78-95.
Titel:The decisive early phase of bone regeneration - Autoren:Maleitzke T, Weber J, Hildebrandt A, Dietrich T, Zhou S, Tsitsilonis S, Keller J
Zeitschrift (Journal):STAR Protoc Jahr:2022;
Titel:Standardized protocol and outcome measurements for the collagen antibody-induced arthritis mouse model - Autoren:Baranowsky A, Jahn D, Jiang S, Yorgan T, Ludewig P, Appelt J, Albrecht KK, Otto E, Knapstein P, Donat A, Winneberger J, Rosenthal L, Köhli P, Erdmann C, Fuchs M, Frosch KH, Tsitsilonis S, Amling M, Schinke T, Keller
Zeitschrift (Journal):Bone Res Jahr:2022; Jahrgang (Volume):10Ausgabe (Issue):(1)
Titel:Procalcitonin is expressed in osteoblasts and limits bone resorption through inhibition of macrophage migration during intermittent PTH treatment - Autoren:Maleitzke T, Hildebrandt A, Dietrich T, Appelt J, Jahn D, Otto E, Zocholl D, Baranowsky A, Duda GN, Tsitsilonis S, Keller J
Zeitschrift (Journal):iScience Jahr:2022; Jahrgang (Volume):25Ausgabe (Issue):(1)
Titel:The calcitonin receptor protects against bone loss and excessive inflammation in collagen antibody-induced arthritis - Autoren:Seemann RJ, Hempel E, Rußow G, Tsitsilonis S, Stöckle U, Märdian S
Zeitschrift (Journal):Front Surg Jahr:2022; Jahrgang (Volume):8
Titel:Clinical and Patient-Related Outcome After Stabilization of Dorsal Pelvic Ring Fractures: A Retrospective Study Comparing Transiliac Fixator (TIFI) and Spinopelvic Fixation (SPF) - Autoren:Chen Z, Wittenberg S, Auer TA, Bashkuev M, Gebert P, Fehrenbach U, Geisel D, Graef F, Maerdian S, Tsitsilonis S
Zeitschrift (Journal):Life (Basel) Jahr:2021; Jahrgang (Volume):11Ausgabe (Issue):(11)
Titel:The Effect of Fat Distribution on the Inflammatory Response of Multiple Trauma Patients-A Retrospective Study - Autoren:Köhli P, Otto E, Jahn D, Reisener MJ, Appelt J, Rahmani A, Taheri N, Keller J, Pumberger M, Tsitsilonis S
Zeitschrift (Journal):Cells Jahr:2021; Jahrgang (Volume):10Ausgabe (Issue):(11)
Titel:Future Perspectives in Spinal Cord Repair: Brain as Saviour? TSCI with Concurrent TBI: Pathophysiological Interaction and Impact on MSC Treatment - Autoren:Appelt J, Tsitsilonis S, Otto E, Jahn D, Köhli P, Baranowsky A, Jiang S, Fuchs M, Bucher CH, Duda GN, Frosch KH, Keller J
Zeitschrift (Journal):Cells Jahr:2021; Jahrgang (Volume):10Ausgabe (Issue):(9)
Titel:Mice Lacking the Calcitonin Receptor Do Not Display Improved Bone Healing
Weitere Publikationen
Ergebnisse filtern
- Autoren:Niemann M, Otto E, Eder C, Youssef Y, Kaufner L, Märdian S
Zeitschrift (Journal): EFORT Open Rev Jahr:2022;
Titel:Coagulopathy management of multiple injured patients - a comprehensive literature review of the European guideline 2019
