
Neuartige Muskuloskeletal Therapien
Trotz der hohen Inzidenz von Muskelverletzungen, degenerativen Gelenk- oder Wirbelsäulenerkrankungen und anderen Muskel-Skelett-Erkrankungen wie Sehnen- oder Knochenpathologien ist das grundlegende Thema - die biologische Regeneration - in der klinischen Praxis noch nicht gelöst. Seit 2006 arbeiten wir an translationalen Therapien im Bereich der muskuloskelettalen Regeneration mit dem Ziel, dem Patienten innovative regenerative Ansätze zu bieten.
Sie befinden sich hier:
Ausgewählte Publikationen
Autoren:Maleitzke T, Niemann M, Zhou S, Lauterbach L, Geissler S, Ort M, Duda GN, Perka C, Stoeckle U, Winkler T
Titel:Regenerative Plasma- und Zelltherapien in der Orthopädie und Unfallchirurgie
Advanced regenerative therapies aim to restore acute and degenerative tissue defects. Platelet-rich plasma (PRP) has emerged as a widely applied treatment approach for various forms of osteoarthritis and tendinopathies. To date, robust data on efficacy and product characteristics are however still scarce. While currently still being researched, mesenchymal cell-based therapies may also facilitate tissue regeneration through paracrine immunomodulation. Regenerative medicine in orthopaedics and trauma surgery will have to focus on safety and long-term-efficacy evidence, to advance into clinical practice in the years to come.
Zeitschrift (Journal):Thieme Jahr:2022;
Autoren:Zhou S, Maleitzke T, Geissler S, Hildebrandt A, Fleckenstein F, Niemann M, Fischer H, Perka C, Duda GN, Winkler T
Titel:Source and Hub of Inflammation - The Infrapatellar Fat Pad and its Interactions with Articular Tissues during Knee Osteoarthritis
Knee osteoarthritis, the most prevalent degenerative joint disorder worldwide, is driven by chronic low-grade inflammation and subsequent cartilage degradation. Clinical data on the role of the Hoffa or infrapatellar fat pad in knee osteoarthritis is however scarce. The infrapatellar fat pad is a richly innervated intracapsular, extrasynovial adipose tissue and an abundant source of adipokines and pro-inflammatory and catabolic cytokines, which may contribute to chronic synovial inflammation, cartilage destruction, and subchondral remodeling during knee osteoarthritis. How the infrapatellar fat pad interacts with neighboring tissues is poorly understood. Here, we review available literature with regard to the infrapatellar fat pad's interactions with cartilage, synovium, bone, menisci, ligaments, and nervous tissue during the development and progression of knee osteoarthritis.
Zeitschrift (Journal):J Orthop Res Jahr:2022;
Autoren:Maleitzke T, Reinke P, Agres AN, Alves SA, Akyüz L, Fleckenstein FN, Bichmann A, Ofir R, Perka C, Duda GN, Winkler T
Titel:Intramuscular and intratendinous placenta-derived mesenchymal stromal-like cell treatment of a chronic quadriceps tendon rupture
We report the case of an 80-year-old male patient with a chronic three-time QTR of his right knee. The quadriceps tendon was reconstructed applying a conventional suture anchor repair procedure combined with a synthetic mesh augmentation and additional intramuscular and intratendineous PLX-PAD cell injections as an individualized treatment approach. No adverse events were reported, and excellent radiological and functional outcomes with a passive range of motion of 0/0/120° knee extension-flexion were observed at the 12 month follow-up.
Zeitschrift (Journal):J Cachexia Sarcopenia Muscle Jahr:2022; Jahrgang (Volume):13Ausgabe (Issue):(1):Seiten (Pages):434-442.
Autoren:Maleitzke T, Hildebrandt A, Weber J, Dietrich T, Appelt J, Jahn D, Zocholl D, Baranowsky A, Duda GN, Tsitsilonis S, Keller K
Titel:Proinflammatory and bone protective role of calcitonin gene-related peptide alpha in collagen antibody-induced arthritis
This study demonstrates a proinflammatory and bone protective role of αCGRP in CAIA. Our data indicate that αCGRP not only enhances joint inflammation, but also controls bone remodelling as part of arthritis resolution. As novel αCGRP inhibitors are currently introduced clinically for the treatment of migraine, their potential impact on RA progression warrants further clinical investigation.
Zeitschrift (Journal):Rheumatology (Oxford) Jahr:2021; Jahrgang (Volume):60Ausgabe (Issue):(4):Seiten (Pages):1996-2009.
Autoren:Winkler T, Perka C, von Roth P, Agres AN, Plage H, Preininger B, Pumberger M, Geissler S, Hagai EL, Ofir R, Pinzur L, Eyal E, Stoltenburg-Didinger G, Meisel C, Consentius C, Streitz M, Reinke P, Duda GN, Volk HD
Titel:Immunomodulatory placental-expanded, mesenchymal stromal cells improve muscle function following hip arthroplasty
In this study we addressed surgical trauma-related muscle injuries resulting from Hip arthroplasty by local intraoperative application of allogeneic placenta-derived, mesenchymal-like adherent cells (PLX-PAD). This cell type was used because of its high regenerative and immunomodulatory potency and we could show that this allogeneic PLX-PAD therapy improved strength and volume of the injured skeletal muscle with a reasonable safety profile. Outcomes could be positively correlated with the modulation of early postoperative stress-related immunological reactions.
Zeitschrift (Journal):J Cachexia Sarcopenia Muscle Jahr:2018; Jahrgang (Volume):9Ausgabe (Issue):(5):Seiten (Pages):880-897.
Publikationen
- Autoren:Mobasheri A, Thudium CS, Bay-Jensen AC, Maleitzke T, Geissler S, Duda GN, Winkler T
Zeitschrift (Journal):Best Pract Res Clin Rheumatol . Jahr:2023;
Titel:Biomarkers for osteoarthritis: Current status and future prospects - Autoren:Shen P, Serve S, Wu P, Liu X, Dai Y, Durán-Hernández N, Nguyen DTM, Fuchs M, Maleitzke T, Reisener MJ, Dzamukova, Nussbaumer K, Brunner TM, Li Y, Holexcka V, Hein GA, Heinrich F, Durek P, Katsoula G, Gwinner C, Jung T, Zeggini E, Winkler T, Mashreghi MF, Pumberger M, Perka C, Löhning M
Zeitschrift (Journal):Proc Natl Acad Sci U S A. Jahr:2023; Jahrgang (Volume):120Ausgabe (Issue):(29)
Titel:NOS inhibition reverses TLR2-induced chondrocyte dysfunction and attenuates age-related osteoarthritis - Autoren:Winkler T, Bell L, Bender A, Trepczynski A, Duda GN, Baur AJD, Damm P
Zeitschrift (Journal):Front Bioeng Biotechno Jahr:2023; Jahrgang (Volume):11
Titel:Periarticular muscle status affects in vivo tibio-femoral joint loads after total knee arthroplasty - Autoren:Maleitzke T, ZhouS, Zocholl D, Fleckenstein FN, Back DA, Plewe JM, Weber J, Winkler T, Stöckle U, Tsitsilonis S, Märdian S
Zeitschrift (Journal):Front Immunol Jahr:2023; Jahrgang (Volume):13
Titel:Routine laboratory parameters predict intensive care unit admission and hospitalization in patients suffering stab injuries - Autoren:Niemann M, Ort M, Lauterbach L, Streitz M, Wilhelm A, Grütz G, Fleckenstein FN, Graef F, Blankenstein A, Reinke S, Stöckle U, Perka C, Duda GN, Geißler S, Winkler T, Maleitzke T
Zeitschrift (Journal):Arthritis Res Ther Jahr:2023; Jahrgang (Volume):25Ausgabe (Issue):(1)
Titel: Individual immune cell and cytokine profiles determine platelet-rich plasma composition - Autoren:Shen P, Wu P, Maleitzke T, Reisener MJ, Heinz GA, Heinrich F, Durek P, Gwinner C, Winkler T, Pumberger M, Perka C, Mashreghi MF, Löhning M
Zeitschrift (Journal):Front Bioeng Biotechnol Jahr:2022; Jahrgang (Volume):10
Titel:Optimization of chondrocyte isolation from human articular cartilage to preserve the chondrocyte transcriptome - Autoren:Maleitzke T, Niemann M, Zhou S, Lauterbach L, Geissler S, Ort M, Duda GN, Perka C, Stoeckle U, Winkler T
Zeitschrift (Journal):Thieme Jahr:2022;
Titel:Regenerative Plasma- und Zelltherapien in der Orthopädie und Unfallchirurgie - Autoren:Heimer CYW, Wu CH, Perka C, Hardt S, Göhler F, Winkler T, Bäcker HC
Zeitschrift (Journal):J Pers Med Jahr:2022; Jahrgang (Volume):12Ausgabe (Issue):(7)
Titel:The Impact of Hip Dysplasia on CAM Impingement - Autoren:Zhou S, Maleitzke T, Geissler S, Hildebrandt A, Fleckenstein F, Niemann M, Fischer H, Perka C, Duda GN, Winkler T
Zeitschrift (Journal):J Orthop Res Jahr:2022;
Titel:Source and Hub of Inflammation - The Infrapatellar Fat Pad and its Interactions with Articular Tissues during Knee Osteoarthritis - Autoren:Haffer H, Bender A, Krump A, Hardt S, Winkler T, Damm P
Zeitschrift (Journal):Front Bioeng Biotechnol Jahr:2022; Jahrgang (Volume):10
Titel:Is Training With Gym Machines Safe After Hip Arthroplasty?-An In Vivo Load Investigation
Weitere Publikationen
Ergebnisse filtern
- Autoren:Märdian S, Maleitzke T, Niemann M, Salmoukas K, Stöckle U
Zeitschrift (Journal):Unfallchirurgie (Heidelb) Jahr:2023; Jahrgang (Volume):126Ausgabe (Issue):(2):Seiten (Pages):89-99.
Titel:[Imaging examination procedures, navigation and minimally invasive procedures in acetabular surgery] - Autoren:Fleckenstein FN, Roesel MJ, Krajewska M, Auer TA, Collettini F, Maleitzke T, Böning G, Torsello GF, Fehrenbach U, Gebauer B
Zeitschrift (Journal):Cancers (Basel) Jahr:2021; Jahrgang (Volume):14Ausgabe (Issue):(1)
Titel:Combining Transarterial Radioembolization (TARE) and CT-Guided High-Dose-Rate Interstitial Brachytherapy (CT-HDRBT): A Retrospective Analysis of Advanced Primary and Secondary Liver Tumor Treatment - Autoren:Engelhardt LJ, Olbricht C, Niemann M, Graw JA, Hunsicker O, Weiss B, Bünger V, Weber-Carstens S, Boie SD, Piper SK, Balzer F, Menk M
Zeitschrift (Journal):J Clin Med Jahr:2022;
Titel:Outcome Comparison of Acute Respiratory Distress Syndrome (ARDS) in Patients with Trauma-Associated and Non-Trauma-Associated ARDS: A Retrospective 11-Year Period Analysis
