Neuartige Muskuloskeletal Therapien
Trotz der hohen Inzidenz von Muskelverletzungen, degenerativen Gelenk- oder Wirbelsäulenerkrankungen und anderen Muskel-Skelett-Erkrankungen wie Sehnen- oder Knochenpathologien ist das grundlegende Thema - die biologische Regeneration - in der klinischen Praxis noch nicht gelöst. Seit 2006 arbeiten wir an translationalen Therapien im Bereich der muskuloskelettalen Regeneration mit dem Ziel, dem Patienten innovative regenerative Ansätze zu bieten.
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Ausgewählte Publikationen
Autoren:Winkler T, Stuhlert MGW, Lieb E, Muller M, von Roth P, Preininger B, Trampuz A, Perka CF
Titel:Outcome of short versus long interval in two-stage exchange for periprosthetic joint infection: a prospective cohort study
For chronic periprosthetic joint infection, a 6-8 week interval is commonly used before re-implantation. We evaluated the influence of a short (< 4 weeks) and long (>/= 4 weeks) prosthesis-freeinterval on reinfection rate and functional outcome of hip and knee periprosthetic joint infection. Our study suggests that two-stage exchange with short interval has a similar outcome than with long interval, when highly active antibiotic therapy is used. Patient inconvenience and care costs due to immobilization were lower when strategies with a short interval were used.
Zeitschrift (Journal):Arch Orthop Trauma Surg Jahr:2019; Jahrgang (Volume):139Ausgabe (Issue):(4):Seiten (Pages):295-303.
Autoren:Winkler T, Perka C, von Roth P, Agres AN, Plage H, Preininger B, Pumberger M, Geissler S, Hagai EL, Ofir R, Pinzur L, Eyal E, Stoltenburg-Didinger G, Meisel C, Consentius C, Streitz M, Reinke P, Duda GN, Volk HD
Titel:Immunomodulatory placental-expanded, mesenchymal stromal cells improve muscle function following hip arthroplasty
In this study we addressed surgical trauma-related muscle injuries resulting from Hip arthroplasty by local intraoperative application of allogeneic placenta-derived, mesenchymal-like adherent cells (PLX-PAD). This cell type was used because of its high regenerative and immunomodulatory potency and we could show that this allogeneic PLX-PAD therapy improved strength and volume of the injured skeletal muscle with a reasonable safety profile. Outcomes could be positively correlated with the modulation of early postoperative stress-related immunological reactions.
Zeitschrift (Journal):J Cachexia Sarcopenia Muscle Jahr:2018; Jahrgang (Volume):9Ausgabe (Issue):(5):Seiten (Pages):880-897.
Publikationen
- Autoren:Maleitzke T, Pumberger M, Gerlach UA, Herrmann C, Slagman A, Henriksen LS, von Mauchenheim F, Hüttermann N, Santos AN, Fleckenstein FN, Rauch G, Märdian S, Perka C, Stöckle U, Möckel M, Lindner T, Winkler T
Zeitschrift (Journal):PLoS One Jahr:2021; Jahrgang (Volume):16Ausgabe (Issue):(2)
Titel:Impact of the COVID-19 shutdown on orthopedic trauma numbers and patterns in an academic Level I Trauma Center in Berlin, Germany - Autoren:Bartek B, Winkler T, Garbe A, Schelberger T, Perka C, Jung T
Zeitschrift (Journal):Knee Surg Sports Traumatol Arthrosc Jahr:2021;
Titel:Bacterial contamination of irrigation fluid and suture material during ACL reconstruction and meniscus surgery : Low infection rate despite increasing contamination over surgery time - Autoren:Fuchs M, Trampuz A, Kirschbaum St, Winkler T, Sass FA
Zeitschrift (Journal):J Clin Med Jahr:2021; Jahrgang (Volume):10Ausgabe (Issue):(4)
Titel:Soluble Pecam-1 as a Biomarker in Periprosthetic Joint Infection - Autoren:Maleitzke T, Maziak N, Plachel F, Winkler T, Moroder P
Zeitschrift (Journal):Arch Orthop Trauma Surg Jahr:2020;
Titel:Can an acute high-grade acromioclavicular joint separation be reduced and stabilized without surgery? A surgeon's experience - Autoren:Winkler T, Duda GN
Zeitschrift (Journal):J Cachexia Sarcopenia Muscle Jahr:2020;
Titel:Predicting Health with Function - How Can Biomechanics "Ride the Tiger"? - Autoren:Maleitzke T, Eckerlin P, Winkler T, Trampuz A
Zeitschrift (Journal):Orthopade Jahr:2020; Jahrgang (Volume):49Ausgabe (Issue):(8):Seiten (Pages):679-684.
Titel:Prevention of infections following open fractures - Autoren:Maleitzke T, Elazaly H, Festbaum Ch, Eder CH, Karczewski D, Perka C, Duda GN, Winkler T
Zeitschrift (Journal):J Clin Med Jahr:2020; Jahrgang (Volume):9Ausgabe (Issue):(7)
Titel:Mesenchymal Stromal Cell-Based Therapy-An Alternative to Arthroplasty for the Treatment of Osteoarthritis? A State of the Art Review of Clinical Trials - Autoren:Eder CH, Schmidt-Bleek K, Geissler S, Sass FA, Maleitzke T, Pumberger M, Perka C, Duda GN, Winkler T
Zeitschrift (Journal):Mol Biol Rep Jahr:2020;
Titel:Mesenchymal Stromal Cell and Bone Marrow Concentrate Therapies for Musculoskeletal Indications: A Concise Review of Current Literature - Autoren:Müller M, Winkler T, Märdian S, Trampuz A, Renz N, Perka C, Karczewski D.
Zeitschrift (Journal):Arch Orthop Trauma Surg Jahr:2019;
Titel:The worst-case scenario: treatment of periprosthetic femoral fracture with coexistent periprosthetic infection-a prospective and consecutive clinical study - Autoren:Gonzalez Moreno M, Wang L, De Masi M, Winkler T, Trampuz A, Di Luca M
Zeitschrift (Journal):J Antimicrob Chemother Jahr:2019; Jahrgang (Volume): May 2. pii: dkz174. doi: 10.1093/jac/dkz174. [Epub ahead of print]
Titel:In vitro antimicrobial activity against Abiotrophia defectiva and Granulicatella elegans biofilms
