Neuartige Muskuloskeletal Therapien

Trotz der hohen Inzidenz von Muskelverletzungen, degenerativen Gelenk- oder Wirbelsäulenerkrankungen und anderen Muskel-Skelett-Erkrankungen wie Sehnen- oder Knochenpathologien ist das grundlegende Thema - die biologische Regeneration - in der klinischen Praxis noch nicht gelöst. Seit 2006 arbeiten wir an translationalen Therapien im Bereich der muskuloskelettalen Regeneration mit dem Ziel, dem Patienten innovative regenerative Ansätze zu bieten.

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Ausgewählte Publikationen

  • Winkler T, Stuhlert MGW, Lieb E, Muller M, von Roth P, Preininger B, Trampuz A, Perka CF

    Outcome of short versus long interval in two-stage exchange for periprosthetic joint infection: a prospective cohort study


    For chronic periprosthetic joint infection, a 6-8 week interval is commonly used before re-implantation. We evaluated the influence of a short (< 4 weeks) and long (>/= 4 weeks) prosthesis-freeinterval on reinfection rate and functional outcome of hip and knee periprosthetic joint infection. Our study suggests that two-stage exchange with short interval has a similar outcome than with long interval, when highly active antibiotic therapy is used. Patient inconvenience and care costs due to immobilization were lower when strategies with a short interval were used.

    Arch Orthop Trauma Surg 2019; 139(4):295-303.

  • Winkler T, Perka C, von Roth P, Agres AN, Plage H, Preininger B, Pumberger M, Geissler S, Hagai EL, Ofir R, Pinzur L, Eyal E, Stoltenburg-Didinger G, Meisel C, Consentius C, Streitz M, Reinke P, Duda GN, Volk HD

    Immunomodulatory placental-expanded, mesenchymal stromal cells improve muscle function following hip arthroplasty


    In this study we addressed surgical trauma-related muscle injuries resulting from Hip arthroplasty by local intraoperative application of allogeneic placenta-derived, mesenchymal-like adherent cells (PLX-PAD). This cell type was used because of its high regenerative and immunomodulatory potency and we could show that this allogeneic PLX-PAD therapy improved strength and volume of the injured skeletal muscle with a reasonable safety profile. Outcomes could be positively correlated with the modulation of early postoperative stress-related immunological reactions.

    J Cachexia Sarcopenia Muscle 2018; 9(5):880-897.


Publikationen

Ergebnisse 1 bis 10 von insgesamt 34


Ergebnisse 1 bis 10 von insgesamt 34