Computational Mechanobiology

Tissues in the musculoskeletal system are exquisitely designed with superb mechanical properties. The tissues are also able to adapt to withstand changing mechanical conditions. The Computational Mechanobiology Group is focused on understanding these two exciting features. Using computer modeling techniques, we seek to understand the mechanical behavior of tissues and their adaptive and regenerative response to mechanical stimuli at the different time and length scales.

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Bone Adaptation to Mechanical Loading

Bone is able to adapt to the mechanical loads placed on it, by adding or removing matrix. We are interested in understanding how local mechanical signals within the bone regulate the local resorption and apposition of bone matrix. To achieve this, we use finite element techniques in combination with novel in vivo microCT image registration methods to correlate the local strain environment to formation and resorption events.

We correlate bone formation and resorption events in bone to the local mechanical environment at their location in order to understand how local mechanical signals drive bone (re)modelling responses.
Quantification of the mechanical regulation of bone adaptation shows age-related alterations (Razi et al., J Bone Miner Res 2015; 30(10):1864-73.)

Publications

Razi H, Birkhold AI, Weinkamer R, Duda GN, Willie BM, Checa S (2015) Aging leads to a dysregulation in mechanically driven bone formation and resorption. J Bone Miner Res. In press

Birkhold AI, Razi H, Weinkamer R, Duda GN, Checa S, Willie BM. (2015) Monitoring in vivo (re)modeling: a computational approach using 4D microCT data to quantify bone surface movements. Bone, 75: 210-21.

Razi H, Birkhold AI, Zaslansky P, Weinkamer R, Duda GN, Willie B, Checa S (2015) Skeletal Maturity leads to a reduction in the strain magnitudes induced within the bone: A murine study. Acta Biomaterialia, 13:301-10

Razi H, Birkhold AI, Zehn M, Duda GN, Willie B, Checa S (2014) A finite element model of in vivo mouse tibial compression loading: influence of boundary conditions. Facta Universitatis. Series: Mechanical Engineering Vol. 12, No 3, 2014, pp. 195 - 207

Birkhold AI, Razi H, Duda GN, Weinkamer R, Checa S, Willie BM. (2014) The influence of age on adaptive bone formation and bone resorption. Biomaterials, 35(34): 9290-301

Birkhold AI, Razi H, Duda GN, Weinkamer R, Checa S, Willie BM. (2014) Mineralizing surface is the main target of mechanical stimulation independent of age: 3D dynamic in vivo morphometry. Bone, 66: 15-25

Willie BM, Birkhold AI, Razi H, Thiele T, Aido M, Kruck B, Schill A, Checa S, Main RP, Duda GN. (2014) Diminished response to in vivo mechanical loading in trabecular and not cortical bone in adulthood of female C57Bl/6 mice coincides with a reduction in deformation to load. Bone, 55(2): 335-46