Tissues in the musculoskeletal system are exquisitely designed with superb mechanical properties. The tissues are also able to adapt to withstand changing mechanical conditions. The Computational Mechanobiology Group is focused on understanding these two exciting features. Using computer modeling techniques, we seek to understand the mechanical behavior of tissues and their adaptive and regenerative response to mechanical stimuli at the different time and length scales.
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Mechanical Principles of Cellular Self-Organization
Cells, the active component of tissues, are continuously interacting with their extracellular matrix (ECM) to maintain, remodel, regenerate or in some cases also degenerate tissue function and properties. Among others, mechanical interactions are fundamental in many physiological and pathological situations such as embryogenesis, wound healing, tumour invasion and connective tissue morphogenesis. We are interested in understanding the mechanical interactions between the cells and the extracellular matrix and their implications for cellular and tissue organization.
Checa S, Rausch M, Petersen A, Kuhl E, Duda G. (2014) The Emergence of Extracellular Matrix Mechanics and Cell Traction Forces as Important Regulators of Cellular Self-organization. Biomechanics and Modeling in Mechanobiology, 14(1):1-13