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A PhD position is available within the Computational Mechanobiology Group at the Julius Wolff Institute (Charite Medical School in Berlin) on the topic of computational optimization of scaffolds to promote bone regeneration within large bone defects.
Although bone has the fascinating ability to self-regenerate after injury, large bone defects often lead to delayed or non-unions. The treatment of these conditions remains a clinical challenge for which scaffold-based strategies appear as a promising approach. In this approach, 3D open porous structures are implanted in the bone defect with the aim to support bone regeneration. Although, preliminary preand clinical data show encouraging results, there is still a need to optimize these scaffolds to ensure successful healing. The growth of new bone within the scaffold is influenced by many factors, such as the scaffold architecture, material properties, patient health condition, etc. The aim of this project is to investigate the potential optimization of scaffolds to promote bone regeneration within large bone defects.
You will develop computer models to simulate the bone healing process and the interaction between mechanical signals (strains) within the healing region and biological processes (e.g. cellular migration, matrix deposition, etc.) taking place. You will simulate the interaction of the bone regeneration process with scaffold-support structures and develop algorithms for the computer optimization of the scaffold design to promote the bone healing process. You will be able to compare model predictions with experimental data from animal studies (e.g. histology, microCT) an d to have access to patient data. The project is part of a research collaboration between several Institutes on the topic of “Personalised Bone Defect Treatment” (Funded by the BMBF).
A degree in Mechanical Engineering/Computer Science/Mathematical Biology or a related discipline - Knowledge of Finite Element Modelling will be advantageous - Experience in Programming is required (e.g. C/C++, Matlab) - High motivation and strong interest in research
What we provide
This position is available for a period of three years. Salary will be commensurate with experience. You will work in a friendly team and in a unique research environment. As a PhD student you will be associated to the Berlin-Brandenburg School of Regenerative Therapies (www.bsrt.de) and benefit from the interaction with international students. Starting date: 1 st October, 2019.
Interested candidates should send a CV, a cover letter and two references that could be contacted. Please email the application to Prof. Checa via email at: sara.checa(at)charite.de