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  • Petersen A, Princ A, Korus G, Ellinghaus A, Leemhuis H, Herrera A, Klaumünzer A, S. Schreivogel S, Woloszyk A, Schmidt-Bleek K, Geissler S, Heschel I, Duda GD

    A biomaterial with a channel-like pore architecture induces endochondral healing of bone defects


    We report on a biomaterial with a channel-like pore architecture that controls cell recruitment and tissue patterning in the early phase of healing. In consequence of extracellular matrix alignment, CD146+ progenitor cell accumulation and restrained vascularization, a highly organized endochondral ossification process is induced in rats.

    Nat Comm 2018;

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  • Eckstein F, Maschek S, Roemer FW, Duda GN, Sharma L, Wirth W.

    Cartilage loss in radiographically normal knees depends on radiographic status of the contralateral knee - data from the Osteoarthritis Initiative


    Radiographically normal knees with contralateral JSN may serve as a human model of early OA, for testing disease modifying drugs in clinical trials designed to prevent cartilage loss before the onset of radiographic change.

    2018; pii: S1063-4584(18):31510-3..

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  • Winkler T, Stuhlert MGW, Lieb E, Müller M, von Roth P, Preininger B, Trampuz A, Perka CF.

    Outcome of short versus long interval in two-stage exchange for periprosthetic joint infection: a prospective cohort study.


    This study suggests that two-stage exchange with short interval has a similar outcome than with long interval, when highly active antibiotic therapy is used. Patient inconvenience and care costs due to immobilization were lower when strategies with a short interval were used.

    Arch Orthop Trauma Surg 2018; doi: 10.1007/s00402-018-3052-4.

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  • Trepczynski A, Kutzner I, Schwachmeyer V, Heller MO, Pfitzner T, Duda GN

    Impact of antagonistic muscle co-contraction on in vivo knee contact forces


    This study shows that treatment of diseased and failed joints should not only be restricted to anatomical reconstruction of static limb axes alignment. The dynamic activation of muscles, as a key modifier of lower limb biomechanics, should also be taken into account and thus also represents a promising target for restoring function, patient mobility, and preventing future joint failure.

    J Neuroeng Rehabil 2018; 15(1):101.

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  • Klein O, Strohschein K, Nebrich G, Fuchs M, Thiele H, Giavalisco P, Duda GN, Winkler T, Kobarg JH, Trede D, Geissler S.

    Unraveling local tissue changes within severely injured skeletal muscles in response to MSC-based intervention using MALDI Imaging mass spectrometry


    We used MALDI imaging mass spectrometry in combination with multivariate statistical strategies to uncover previously unknown peptide alterations within severely injured skeletal muscles. Our analysis revealed that very early molecular alterations in response to MSC-TX occur largely in the region adjacent to the trauma and only to a small extent in the actual trauma region.

    Sci Rep 2018; 8(1):12677.

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  • Lueckgen A, Garske DS, Ellinghaus A, Desai RM, Stafford AG, Mooney DJ, Duda GN, Cipitria A.

    Hydrolytically-degradable click-crosslinked alginate hydrogels


    Degradable biomaterials aim to recapitulate the dynamic microenvironment that cells are naturally exposed to. By oxidizing the alginate polymer backbone, thereby rendering it susceptible to hydrolysis, and crosslinking it via norbornene-tetrazine click chemistry, we can control rheological, mechanical, and degradation properties of resulting hydrogels. Chemical modifications were confirmed by nuclear magnetic resonance (NMR) and the resulting mechanical properties measured by rheology and unconfined compression testing, demonstrating that these are both a function of norbornene coupling and oxidation state.

    Biomaterials 2018; 181:189-198.

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